Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats

被引:28
作者
Nisar, Jaweria [1 ]
Mustafa, Imtiaz [1 ]
Anwar, Haseeb [1 ]
Sohail, Muhammad Umar [1 ]
Hussain, Ghulam [1 ]
Ullah, Muhammad Irfan [2 ]
Faisal, Muhammad Naeem [3 ]
Bukhari, Shazia Anwer [4 ]
Basit, Abdul [5 ]
机构
[1] Govt Coll Univ, Dept Physiol, 2nd Floor,Yousuf Block, Faisalabad 38040, Pakistan
[2] Bahauddin Zakariya Univ, Fac Vet Sci, Dept Pathobiol, Multan, Pakistan
[3] Univ Agr Faisalabad, Inst Pharm Physiol & Pharmacol, Faisalabad, Pakistan
[4] Govt Coll Univ, Dept Appl Chem & Biochem, Faisalabad, Pakistan
[5] Chenab Breeding Area, Remount Off, Faisalabad, Pakistan
关键词
hepatoprotective; hypercholesterolemia; immunomodulatory; Lentinus edodes; medicinal mushrooms; oxidative stress; OXIDATIVE STRESS; LIVER-INJURY; SYMBIOTIC SUPPLEMENTATION; IMMUNITY; PROTEIN; POLYSACCHARIDES; PARAOXONASE; PROTECTION; EXTRACTS; MYCELIA;
D O I
10.1615/IntJMedMushrooms.2017024504
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lentinus edodes is a culinary-medicinal mushroom that has an established history of use in Asian therapies. The mushroom offers well-documented beneficial health effects such as antihypercholesterolemic, antitumor, and antibacterial activities. In this study, dried powder of L. edodes fruiting bodies was used to evaluate immunomodulatory, hepatoprotective, and antioxidant effects in hypercholesterolemic rats. Albino rats (n = 24) were divided into 3 groups: the control (CON) group, the hypercholesterolemia-only group (HCG), and the L. edodes group (LEG). Hypercholesterolemia was induced in rats in the HCG and LEG by feeding cholesterol and cholic acid in a chow maintenance diet (CMD) for 24 days. The CON group was fed the CMD throughout the experiment. The HCG continued on the high-cholesterol diet without any L. edodes supplement. The LEG was fed the high-cholesterol diet supplemented with L. edodes for an additional 42 days. Various biological health biomarkers, such as total antioxidant capacity, total oxidant status, arylesterase, paraoxonase activity, and liver enzymes in serum were studied to evaluate antioxidant and hepatoprotective responses. Cell-mediated immunity was evaluated in each group through a delayed type of hypersensitivity reaction. The total oxidant status decreased significantly (P = 0.05) after administration of L. edodes in the diet. The cell-mediated immune response significantly increased (P = 0.05) in the LEG. The significant decrease in liver enzymes supports the hepatoprotective effect of L. edodes. In conclusion, the results show the immunomodulatory, hepatoprotective, and antioxidant activities of L. edodes supplementation in hypercholesterolemic rats.
引用
收藏
页码:981 / 990
页数:10
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