Villarinol, a new Alkenoyloxyalkenol Derivative from the Endemic Philippine Rubiaceae species Villaria odorata

被引：0
|
作者：
Macabeo, Allan Patrick G. [1 ,2 ]
Avila, Jalil A. [1 ]
Alejandro, Grecebio Jonathan D. [3 ]
Franzblau, Scott G. [4 ]
Kouam, Simeon F. [5 ]
Hussain, Hidayat [5 ]
Krohn, Karsten [5 ]
机构：
[1] Univ Santo Tomas, Phytochem & Organ Synth Lab, Res Ctr Nat & Appl Sci, Manila 1015, Philippines
[2] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany
[3] Univ Santo Tomas, Res Ctr Nat Sci, Plant Sci Lab, Manila 1015, Philippines
[4] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL 60612 USA
[5] Univ Gesamthsch Paderborn, Dept Chem, D-33098 Paderborn, Germany
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 06期
关键词：
Villaria odorata; Rubiaceae; Alkenoyloxy alkenol; beta-Sitosterol; 4-Hydroxybenzaldehyde; MYCOBACTERIUM-TUBERCULOSIS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Villarinol (1), a new alkenoyloxy alkenol metabolite, has been isolated from the dichloromethane extract of Villaria odorata, an endemic Rubiaceae Philippine plant, along with the known compounds stigmasterol and 4-hydroxybenzaldehyde. The structure of 1 was elucidated on the basis of spectroscopic and spectrometric studies. The extracts of V. odorata exhibited moderate inhibition against Mycobacterium tuberculosis H(37)Rv, based on the colorimetric microplate alamar blue assay.
引用
收藏
页码：779 / 780
页数：2
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