Similar mechanisms regulate protein exocytosis from the salivary glands of ixodid and argasid ticks

被引：11

作者：

Maritz-Olivier, C ^{[1
]}

Louw, AI ^{[1
]}

Neitz, AWH ^{[1
]}

机构：

[1] Univ Pretoria, Dept Biochem, ZA-0002 Pretoria, South Africa

来源：

JOURNAL OF INSECT PHYSIOLOGY | 2005年 / 51卷 / 12期

关键词：

exocytosis; dopamine; calcium; G-proteins; Na+K+-ATPases; phospholipase C; phosphatidyl inositol 3-kinases;

D O I：

10.1016/j.jinsphys.2005.08.012

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Numerous bioactive compounds are secreted from large dense core granules in tick salivary glands during feeding in response to tin external stimulus. Investigations into the signalling pathways regulating secretion indicated that they are similar for Argasidae(fast-feeding ticks) and Ixodidae (slow-feeding ticks), but differ in their sensitivity to prostaglandin E-2. In both cases. dopamine is the external signal for inducing exocytosis. Dopamine-induced exocytosis was shown to be strongly calcium dependant, Firstly. it requires extracellular calcium via a L-type voltage-gated calcium channel located on the plasma membrane and, secondly, intracellular calcium which is released presumably in response to inositol 1.4,5-triphosphate (IP3). Pathways Such as the activation of phospholipase C, inositol-phosphate kinases, G-proteins, GTPases and Na K -ATPases have been shown to be essential. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1390 / 1396

页数：7

共 14 条

[1] Secretory granule exocytosis [J].