Association between the G-protein β3 subunit C825T polymorphism with essential hypertension: a meta-analysis in Han Chinese population

被引:5
作者
Lu, Jiapeng [1 ,2 ]
Guo, Qingqing [2 ]
Zhang, Ling [1 ,2 ]
Wang, Wei [1 ,2 ,3 ]
机构
[1] Capital Med Univ, Sch Publ Hlth & Family Med, Dept Epidemiol & Biostat, Beijing 100069, Peoples R China
[2] Beijing Municipal Key Lab Clin Epidemiol, Beijing 100069, Peoples R China
[3] Edith Cowan Univ, Sch Med Sci, Perth, WA 6027, Australia
关键词
Hypertension; Genetic association study; Systematic review; Han Chinese; Meta-analysis; SALT-SENSITIVITY; CARDIOVASCULAR-DISEASE; 825T ALLELE; GENE; OBESITY; VARIANT; EPIDEMIOLOGY; PREVALENCE; JAPANESE; SODIUM;
D O I
10.1007/s11033-012-1762-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We aimed to evaluate the contribution of the G-protein beta 3 subunit C825T (GNB3-C825T) polymorphism to essential hypertension (EH) in Han Chinese population by performing meta-analysis. A meta-analysis was performed in 12 case-control genetic association studies including 3,020 hypertension patients and 2,790 controls from MEDLINE (PubMed) and the China National Knowledge Infrastructure platforms. The STATA 10.0 software was used in analysis. Overall, there was no significant association between the GNB3-C825T polymorphism and EH in neither additive [TT vs. CC: OR (95 % CI) = 1.11 (0.74-1.69), P = 0.61; TC vs. CC: OR (95 % CI) = 1.08 (0.89-1.31), P = 0.42], nor dominant [TT + TC vs. CC: OR (95 % CI) = 1.11 (0.86-1.42), P = 0.43] and nor recessive [TT vs. TC + CC: OR (95 % CI) = 1.04 (0.75-1.44), P = 0.81] genetic models. Although further subgroup analysis found statistically significant results [T vs. C: OR (95 % CI) = 1.50 (1.05-2.15), P = 0.03] in the southern population, but after exclusion one particular study, the significant association was disappeared. No significant result was found in the northern Han Chinese population. There was no significant association identified between GNB3-C825T polymorphism and EH in Han Chinese population. Further larger sample and well-designed studies are needed to assess the genetic association particularly in the southern Han Chinese population.
引用
收藏
页码:8937 / 8944
页数:8
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