Rescue therapy with tacrolimus for a patient with severe ulcerative colitis refractory to combination leukocytapheresis and high-dose corticosteroid therapy

被引：4

作者：

Nakase, Hiroshi ^{[1
]}

Mikami, Sakae ^{[1
]}

Matsuura, Minoru ^{[1
]}

Ueno, Satoru ^{[1
]}

Uza, Norimitsu ^{[1
]}

Inoue, Satoko ^{[1
]}

Kitamura, Hiroshi ^{[1
]}

Kasahara, Katsuhiro ^{[1
]}

Yoshino, Takuya ^{[1
]}

Takeda, Yasuhiro ^{[1
]}

Chiba, Tsutomu ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 11期

关键词：

ulcerative colitis; tacrolimus; leykocytapheresis;

D O I：

10.2169/internalmedicine.46.6219

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A19-year-old man complaining of severe diarrhea and hematochezia was admitted to our hospital. Endoscopic findings and laboratory data revealed that he had ulcerative colitis (UC). Despite combination therapy with high-dose corticosteroids and intensive granulocytapheresis, his condition did not improve. Therefore, we initiated tacrolimus therapy. Intravenous administration of tacrolimus with a trough level of 10 to 15 ng/ml relieved his abdominal symptoms within 1 week. The patient experienced no UC relapse 1 year after treatment with oral tacrolimus. Tacrolimus is a promising therapy for patients with UC refractory to the combination of high-dose corticosteroids and leukocytapheresis.

引用

页码：717 / 720

页数：4

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