Effect of simavastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes

被引：12
作者：
Yin Xiaoming [1 ]
Tu Ling [2 ]
Yang Huiqing [1 ]
机构：
[1] Anqing Municipal Hosp, Dept Geriatr Med, Anqing 246003, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Integrat, Wuhan 430030, Peoples R China
来源：
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2007年 / 27卷 / 03期
关键词：
obesity; adipocyte; adiponectin; simvastatin; interleukin-6;
D O I：
10.1007/s11596-007-0308-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In order to investigate the effects of simvastatin on secretion and mRNA expression of interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes, mouse 3T3-L1 adipocytes were stimulated with lipopolysaccharide (LPS). Production and mRNA expression of IL-6 and adiponectin in 3T3-L1 adipocytes were measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. The results showed that simvastatin could significantly suppress LPS-induced IL-6 production and mRNA expression in adipocytes (P < 0.05), but increase the LPS-induced adiponectin secretion and mRNA expression in a dose-dependent manner (P < 0.05). It was suggested that simvastatin could exert beneficial effects on prevention of obesity-induced metabolic changes in adipocytes.
引用
收藏
页码：248 / 251
页数：4
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