Effect of simavastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes

被引：12

作者：

Yin Xiaoming ^{[1
]}

Tu Ling ^{[2
]}

Yang Huiqing ^{[1
]}

机构：

[1] Anqing Municipal Hosp, Dept Geriatr Med, Anqing 246003, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Integrat, Wuhan 430030, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2007年 / 27卷 / 03期

关键词：

obesity; adipocyte; adiponectin; simvastatin; interleukin-6;

D O I：

10.1007/s11596-007-0308-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to investigate the effects of simvastatin on secretion and mRNA expression of interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes, mouse 3T3-L1 adipocytes were stimulated with lipopolysaccharide (LPS). Production and mRNA expression of IL-6 and adiponectin in 3T3-L1 adipocytes were measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. The results showed that simvastatin could significantly suppress LPS-induced IL-6 production and mRNA expression in adipocytes (P < 0.05), but increase the LPS-induced adiponectin secretion and mRNA expression in a dose-dependent manner (P < 0.05). It was suggested that simvastatin could exert beneficial effects on prevention of obesity-induced metabolic changes in adipocytes.

引用

页码：248 / 251

页数：4

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