UPDATED UNDERSTANDING OF THE MOLECULAR TARGETS OF RADIOIODINE IN DIFFERENTIATED THYROID CANCER

被引：1

作者：

Zhang, Y. ^{[1
]}

Zou, W. ^{[2
]}

Zhu, X. ^{[1
]}

Jiang, L. ^{[1
]}

Gui, C. ^{[1
]}

Fan, Q. ^{[1
]}

Tu, Y. ^{[3
]}

Chen, J. ^{[1
]}

机构：

[1] Hubei Canc Hosp, Dept Head & Neck Surg, Wuhan 430079, Peoples R China

[2] First Peoples Hosp Yichang, Dept Gen Surg 2, Yichang, Hubei, Peoples R China

[3] Liuzhou Tradit Chinese Med Hosp, Dept Otolaryngol & Head & Neck Surg, Liuzhou, Guangxi, Peoples R China

来源：

ACTA ENDOCRINOLOGICA-BUCHAREST | 2022年 / 18卷 / 01期

关键词：

Radioactive iodine (RAI); thyroid cancer; iodine transport system; I-; uptake; RADIOACTIVE IODINE THERAPY; SODIUM/IODIDE SYMPORTER; NECK RECURRENCE; CARCINOMA; OUTCOMES; PENDRIN; CELLS; EXPRESSION; EFFLUX; NIS;

D O I：

10.4183/aeb.2022.86

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Radioactive iodine (RAI) therapy is a mainstay adjuvant treatment for thyroid cancer. Administration of RAI therapy after total or near-total thyroidectomy has shown a survival advantage in numerous properly selected patients. However, the role of RAI therapy after reoperation for persistent or recurrent differentiated thyroid carcinomas (DTCs) is unclear. One reason may be the possible downregulation of the I- transport system after primary surgery. RAI is transported by the sodium iodide symporter (NIS), PENDRIN, anoctamin 1 (ANO1) and cystic fibrosis transmembrane conductance regulator (CFTR) and emits beta particles that destroy follicular cells. The identification of pathways of iodide (I-) transport has allowed use of the transport system to render tumours susceptible to RAI treatment via gene therapy. This review focuses on the effect of RAI therapy in follicular cell-derived thyroid cancers and offers potential novel targets that enable improved radioiodine uptake and thus an improved prognosis of thyroid cancer.

引用

页码：86 / 92

页数：7

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