Characterization of Pancreatic Tumors with Quantitative Perfusion Analysis in Contrast-Enhanced Harmonic Endoscopic Ultrasonography

被引：27

作者：

Omoto, Shunsuke ^{[1
]}

Takenaka, Mamoru ^{[1
]}

Kitano, Masayuki ^{[4
]}

Miyata, Takeshi ^{[1
]}

Kamata, Ken ^{[1
]}

Minaga, Kosuke ^{[1
]}

Arizumi, Tadaaki ^{[1
]}

Yamao, Kentaro ^{[1
]}

Imai, Hajime ^{[1
]}

Sakamoto, Hiroki ^{[1
]}

Harwani, Yogesh ^{[1
]}

Sakurai, Toshiharu ^{[1
]}

Watanabe, Tomohiro ^{[1
]}

Nishida, Naoshi ^{[1
]}

Takeyama, Yoshifumi ^{[2
]}

Chiba, Yasutaka ^{[3
]}

Kudo, Masatoshi ^{[1
]}

机构：

[1] Kindai Univ, Fac Med, Dept Gastroenterol & Hepatol, 377-2 Ohnohigashi, Osakasayama, Osaka 5898511, Japan

[2] Kindai Univ, Fac Med, Dept Surg, Osakasayama, Japan

[3] Kindai Univ, Fac Med, Clin Res Ctr, Div Biostat, Osakasayama, Japan

[4] Wakayama Med Univ, Sch Med, Dept Internal Med 2, Wakayama, Japan

来源：

ONCOLOGY | 2017年 / 93卷

关键词：

Contrast-enhanced harmonic endoscopic ultrasonography; Quantitative perfusion analysis; Pancreatic carcinoma; Time-intensity curve; AUTOIMMUNE PANCREATITIS; DIFFERENTIAL-DIAGNOSIS; ULTRASOUND; MASSES; EUS; CARCINOMA; CANCER;

D O I：

10.1159/000481231

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: This study evaluated whether quantitative perfusion analysis with contrast-enhanced harmonic (CH) endoscopic ultrasonography (EUS) characterizes pancreatic tumors, and compared the hemodynamic parameters used to diagnose pancreatic carcinoma. Methods: CH-EUS data from pancreatic tumors of 76 patients were retrospectively analyzed. Time-intensity curves (TIC) were generated to depict changes in signal intensity over time, and 6 parameters were assessed: baseline intensity, peak intensity, time to peak, intensity gain, intensity at 60 s (I-60), and reduction rate. These parameters were compared between pancreatic carcinomas (n = 41), inflammatory pseudotumors (n = 14), pancreatic neuroendocrine tumors (n = 14), and other tumors (n = 7). All 6 TIC parameters and subjective analysis for diagnosing pancreatic carcinoma were compared. Results: Values of peak intensity and I-60 were significantly lower and time to peak was significantly longer in the groups with pancreatic carcinomas than in the other 3 tumor groups (p < 0.05). Reduction rate was significantly higher in pancreatic carcinomas than in pancreatic neuroendocrine tumors (p < 0.05). Areas under the receiver-operating characteristic curves for the diagnosis of pancreatic carcinoma using subjective analysis, baseline intensity, peak intensity, intensity gain, I-60, time to peak, and reduction rate, were 0.817, 0.664, 0.810, 0.751, 0.845, 0.777, and 0.725, respectively. I-60 was the most accurate parameter for differentiating pancreatic carcinomas from the other groups, giving values of sensitivity/specificity of 92.7/68.6% when optimal cutoffs were chosen. Conclusions: In pancreatic carcinomas, TIC patterns were markedly different from the other tumor types, with I-60 being the most accurate diagnostic parameter. Quantitative perfusion analysis is useful for differentiating pancreatic carcinomas from other pancreatic tumors. (C) 2017 S. Karger AG, Basel

引用

页码：55 / 60

页数：6

共 16 条

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