A Phase II Open-Label, Ac220 Monotherapy Efficacy Study In Patients with Refractory/Relapsed Flt3-Itd Positive Acute Myeloid Leukemia: Updated Interim Results

被引:0
|
作者
Cortes, Jorge E. [1 ]
Perl, Alexander E. [2 ]
Smith, Catherine C. [3 ]
Kovacsovics, Tibor [4 ]
Dombret, Herve [5 ]
Dohner, Hartmut [6 ]
Steffen, Bjorn [7 ]
Pigneux, Arnaud [8 ]
Rousselot, Philippe [9 ]
Krauter, Juergen [10 ]
Martinelli, Giovanni [11 ]
Estey, Elihu H. [12 ]
Burnett, Alan K. [13 ]
Ho, Anthony D. [14 ]
Ifrah, Norbert [15 ]
de Witt, Theo [16 ]
Corringham, Robert [17 ]
James, Joyce [17 ]
Lilienfeld, David [17 ]
Leo, Eugen [17 ]
Gammon, Guy [17 ]
Levis, Mark J. [18 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[2] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[3] Univ Calif San Francisco, Dept Med, Div Hematol Oncol, San Francisco, CA USA
[4] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA
[5] Univ Paris 07, Hop St Louis, AP HP, EA 3518, Paris, France
[6] Univ Ulm, Dept Internal Med 3, D-7900 Ulm, Germany
[7] Klinikum JW Goethe Univ Frankfurt Main, Frankfurt, Germany
[8] CHU Bordeaux, Pessac, France
[9] Univ Versailles St Quentin Yvelines, Hop Versailles, Le Chesnay, France
[10] Hannover Med Sch, D-3000 Hannover, Germany
[11] Univ Bologna, Sch Med, Seragnoli Inst Hematol, Bologna, Italy
[12] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA
[13] Cardiff Univ, Sch Med, Cardiff, S Glam, Wales
[14] Univ Heidelberg, Dept Hematol & Oncol, Heidelberg, Germany
[15] CHU Angers, Serv Hematol, Angers, France
[16] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands
[17] Ambit Biosci, San Diego, CA USA
[18] Johns Hopkins Univ, Div Hematol Malignancies, Dept Oncol, Baltimore, MD USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1105 / 1105
页数:1
相关论文
共 50 条
  • [41] Bisantrene in Combination with Fludarabine and Clofarabine As Salvage Therapy for Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)- an Open-Label, Phase II, Study
    Danylesko, Ivetta
    Shimoni, Avichai
    Avigdor, Abraham
    Kedmi, Meirav
    Shem-Tov, Noga
    Yerushalmi, Ronit
    Sasson, Maya
    Dominissini, Dan
    Andersson, Borje S.
    Nagler, Arnon
    BLOOD, 2023, 142
  • [42] Safety and Efficacy of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Mantle Cell Lymphoma: A Multicenter, Open-Label, Phase II Study
    Song, Yuqin
    Song, Yongping
    Liu, Lihong
    Zhang, Mingzhi
    Li, Zhiming
    Ji, Chunyan
    Xu, Wei
    Liu, Ting
    Xu, Bing
    Wang, Xin
    Gao, Sujun
    Zhang, Huilai
    Hu, Yu
    Li, Yan
    Cheng, Ying
    Yang, Haiyan
    Cao, Junning
    Zhu, Zunmin
    Hu, Jianda
    Zhang, Wei
    Jing, Hongmei
    Ding, Kaiyang
    Lu, Zhengguang
    Zhang, Bin
    Zhao, Renbin
    Xu, Zhixin
    Zhu, Jun
    BLOOD, 2019, 134
  • [43] Combination of Sorafenib and 5-Azacytidine Has Significant Activity in Patients with Relapsed/Refractory or Untreated Acute Myeloid Leukemia and FLT3-ITD mutation
    Ravandi, Farhad
    Alattar, Mona Lisa
    Levis, Mark J.
    Garcia-Manero, Guillermo
    Richie, Mary A.
    Daver, Naval G.
    Faderl, Stefan
    Andreeff, Michael
    Borthakur, Gautam
    Burger, Jan A.
    Kadia, Tapan M.
    Grunwald, Michael R.
    Dellasala, Sara E.
    Cortes, Jorge E.
    Kantarjian, Hagop M.
    BLOOD, 2012, 120 (21)
  • [44] COMBINATION OF SORAFENIB AND 5-AZACYTIDINE HAS SIGNIFICANT ACTIVITY IN PATIENTS WITH RELAPSED/REFRACTORY OR UNTREATED ACUTE MYELOID LEUKEMIA AND FLT3-ITD MUTATION
    Ravandi, Farhad
    Alattar, Mona Lisa
    Levis, Mark
    Garcia-Manero, Guillermo
    Richie, Mary A.
    Daver, Naval
    Faderl, Stefan
    Borthakur, Gautam
    Burger, Jan
    Kadia, Tapan
    Grunwald, Michael
    Dellasala, Sara
    Cortes, Jorge
    Kantarjian, Hagop
    ANNALS OF HEMATOLOGY, 2013, 92 : S19 - S20
  • [45] A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia
    Smith, Catherine C.
    Levis, Mark J.
    Frankfurt, Olga
    Pagel, John M.
    Roboz, Gail J.
    Stone, Richard M.
    Wang, Eunice S.
    Severson, Paul L.
    West, Brian L.
    Le, Mai H.
    Kayser, Sabine
    Lam, Bao
    Hsu, Henry H.
    Zhang, Chao
    Bollag, Gideon
    Perl, Alexander E.
    BLOOD ADVANCES, 2020, 4 (08) : 1711 - 1721
  • [46] PHASE II STUDY OF SORAFENIB AND 5-AZACYTIDINE (AZA) IN PATIENTS WITH RELAPSED, REFRACTORY OR UNTREATED AML AND FLT3-ITD MUTATION
    Ravandi, Farhad
    Alattar, Mona Lisa
    Levis, Mark
    Faderl, Stefan
    Burger, Jan
    Grunwald, Michael
    Cortes, Jorge
    Kantarjian, Hagop
    ANNALS OF HEMATOLOGY, 2013, 92 : S16 - S16
  • [47] Efficacy and Safety of Clifutinib, a Novel, Highly Selective, Oral FLT3 Inhibitor, in Patients with FLT3-Mutated Relapsed or Refractory Acute Myeloid Leukemia:Updated Results from a Phase I Study
    Jin, Jie
    Wang, Huafeng
    Yu, Wen-Juan
    Ge, Zheng
    Wei, Xudong
    Li, Yuhua
    Jiang, Zhongxing
    Li, Yiqing
    Du, Xin
    Yang, Linhua
    Lin, Lie
    Wang, Jishi
    Yao, Yazhou
    Hu, Xiaoping
    Lan, Jianping
    Deng, Xiuzhi
    Chen, Tong
    Feng, Xianqi
    Li, Dengju
    Hou, Ming
    Fu, Rong
    Huang, Siyong
    Wang, Jingbo
    Du, Xin
    Yang, Hui
    Yang, Haiping
    Jiang, Yingzhi
    Wang, Zhijie
    Li, Deng
    Liu, Bing
    Kang, Ning
    Zhuang, Yulei
    Zhang, Yingjun
    BLOOD, 2023, 142
  • [48] Gilteritinib Versus Salvage Chemotherapy for Relapsed/Refractory FLT3-Mutated Acute Myeloid Leukemia: A Phase 3, Randomized, Multicenter, Open-Label Trial in Asia
    Wang, Jianxiang
    Jiang, Bin
    Li, Jian
    Liu, Ligen
    Du, Xin
    Jiang, Hao
    Hu, Jianda
    Yuan, Menghe
    Sakatani, Taishi
    Kadokura, Takeshi
    Takeuchi, Masato
    Izuka, Shunsuke
    Girshova, Larisa
    Tan, Jerome
    Bondarenko, Sergey N.
    Wong, Lily L. L.
    Khuhapinant, Archrob
    Martynova, Elena
    Hasabou, Nahla
    Tiu, Ramon V.
    BLOOD, 2021, 138
  • [49] Efficacy and safety of venetoclax in combination with cytarabine and azacitidine (VAA) in relapsed/refractory acute myeloid leukemia: An open-label, single-arm, phase II study.
    You, Liangshun
    Liu, Yi
    Mai, Wenyuan
    Zhou, De
    Xie, Wanzhuo
    Mao, Liping
    Zhou, Xinping
    Tong, Hongyan
    Jin, Jie
    Meng, Haitao
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [50] Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial (vol 20, pg 986, 2019)
    Cortes, J. E.
    Khaled, S.
    Martinelli, G.
    LANCET ONCOLOGY, 2019, 20 (07): : E346 - E346