Pinus halepensis Essential Oil Ameliorates Aβ1-42-Induced Brain Injury by Diminishing Anxiety, Oxidative Stress, and Neuroinflammation in Rats

被引：8
作者：
Postu, Paula Alexandra [1 ,2 ]
Mihasan, Marius [2 ]
Gorgan, Dragos Lucian [2 ]
Sadiki, Fatima Zahra [3 ]
El Idrissi, Mostafa [3 ]
Hritcu, Lucian [2 ]
机构：
[1] Reg Inst Oncol, Ctr Fundamental Res & Expt Dev Translat Med Trans, Iasi 7000483, Romania
[2] Alexandru Ioan Cuza Univ, Fac Biol, Dept Biol, Iasi 700506, Romania
[3] Moulay Ismail Univ, Fac Sci Meknes, Dept Chem, Lab Mol Chem & Nat Subst, Meknes 11201, Morocco
来源：
BIOMEDICINES | 2022年 / 10卷 / 09期
关键词：
amyloid beta peptide; Pinus halepensis; essential oil; anxiety; depression; Alzheimer's disease; ELEVATED PLUS-MAZE; ALZHEIMERS-DISEASE; ALPHA-PINENE; BETA; DEPRESSION; DEMENTIA; ASSAY; MICE; INTERLEUKIN-1-BETA; GLUTATHIONE;
D O I：
10.3390/biomedicines10092300
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Pinus L. genus comprises around 250 species, being popular worldwide for their medicinal and aromatic properties. The present study aimed to evaluate the P. halepensis Mill. essential oil (PNO) in an Alzheimer's disease (AD) environment as an anxiolytic and antidepressant agent. The AD-like symptoms were induced in Wistar male rats by intracerebroventricular administration of amyloid beta1-42 (A beta 1-42), and PNO (1% and 3%) was delivered to A beta 1-42 pre-treated rats via inhalation route for 21 consecutive days, 30 min before behavioral assessments. The obtained results indicate PNO's potential to relieve anxious-depressive features and to restore redox imbalance in the rats exhibiting AD-like neuropsychiatric impairments. Moreover, PNO presented beneficial effects against neuroinflammation and neuroapoptosis in the A beta 1-42 rat AD model.
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页数：19
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