Drug-induced hypersensitivity syndrome in pediatric patients

被引：65

作者：

Carroll, MC

Yueng-Yue, NB

Esterly, NB

Drolet, BA

机构：

[1] Med Coll Wisconsin, Dept Dermatol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

来源：

PEDIATRICS | 2001年 / 108卷 / 02期

关键词：

drug-induced hypersensitivity syndrome; hypersensitivity syndrome; hypersensitivity syndrome reaction; antiepileptic hypersensitivity syndrome; drug reaction;

D O I：

10.1542/peds.108.2.485

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The antiepileptic hypersensitivity syndrome is a severe, multiorgan reaction to oral antiepileptics that manifests as fever, rash, lymphadenopathy, and hepatitis. This same reaction pattern also has been described following administration of a few unrelated medications. We report on 11 patients who had drug-induced hypersensitivity syndrome and were admitted to our pediatric service and review 94 cases of this syndrome in pediatric patients identified from the literature. We undertook this study to summarize the findings and alert clinicians to the severe internal organ involvement that can occur with this syndrome.

引用

收藏

页码：485 / 493

页数：9

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