Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with stable angina

被引：41

作者：

Fan, Zeyuan ^{[1
]}

Ji, Hanhua ^{[1
]}

Li, Yang ^{[1
]}

Jian, Xinwen ^{[1
]}

Li, Li ^{[1
]}

Liu, Tao ^{[1
]}

机构：

[1] Peking Univ, Civil Aviat Clin Med Coll, Civil Aviat Gen Hosp, Dept Cardiovasc Dis, Beijing, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 11期

关键词：

monocyte-to-lymphocyte ratio; necrotic core; plaque vulnerability; stable angina; thin cap fibrous atheroma; INTRAVASCULAR ULTRASOUND; ARTERY-DISEASE; SYNTAX SCORE; NEUTROPHIL; ATHEROSCLEROSIS; ASSOCIATION; GUIDELINES; MANAGEMENT; PREDICTS; EVENTS;

D O I：

10.2217/bmm-2017-0235

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina. Methods: 133 patients with stable angina were enrolled. Results: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2.61; p = 0.025). MLR could differentiate thin cap fibrous atheroma with a sensitivity of 73.7% and a specificity of 61.8%. MLR level was positively correlated with the percentage of necrotic core (NC) area at the sites of minimum lumen area and the largest NC area, and positively related to the percentage of NC volume. Conclusion: Circulating MLR level has potential in identifying the vulnerable plaques in the setting of stable angina.

引用

收藏

页码：979 / 990

页数：12

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