Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation

被引：3

作者：

Cambier, Linda ^{[1
]}

Pomies, Pascal ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, CRBM, Univ Montpellier 1,UMR5237, F-34293 Montpellier 5, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 409卷 / 04期

关键词：

Skeletal muscle; Myogenesis; PDZ-LIM protein; LIM motif; Nuclear translocation; SERUM RESPONSE FACTOR; PDZ-LIM PROTEIN; SEPTATE JUNCTIONS; DOMAIN; GENE; ELEGANS; ALP; HOMEODOMAIN; ACTIVATION; MOTIF;

D O I：

10.1016/j.bbrc.2011.05.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The skALP isoform has been shown to play a critical role in actin organization and anchorage within the Z-discs of skeletal muscles, but no data is available on the function of the smALP isoform in skeletal muscle cells. Here, we show that upon induction of differentiation a nuclear translocation of smALP from the cytoplasm to the nucleus of C2C12 myoblasts, concomitant to an up-regulation of the protein expression, occurs in parallel with the nuclear accumulation of myogenin. Moreover, we demonstrate that the LIM domain of smALP is essential for the nuclear translocation of the protein. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：628 / 633

页数：6

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