Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation

被引：3
|
作者：
Cambier, Linda [1 ]
Pomies, Pascal [1 ]
机构：
[1] Univ Montpellier 2, CNRS, CRBM, Univ Montpellier 1,UMR5237, F-34293 Montpellier 5, France
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 409卷 / 04期
关键词：
Skeletal muscle; Myogenesis; PDZ-LIM protein; LIM motif; Nuclear translocation; SERUM RESPONSE FACTOR; PDZ-LIM PROTEIN; SEPTATE JUNCTIONS; DOMAIN; GENE; ELEGANS; ALP; HOMEODOMAIN; ACTIVATION; MOTIF;
D O I：
10.1016/j.bbrc.2011.05.054
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The skALP isoform has been shown to play a critical role in actin organization and anchorage within the Z-discs of skeletal muscles, but no data is available on the function of the smALP isoform in skeletal muscle cells. Here, we show that upon induction of differentiation a nuclear translocation of smALP from the cytoplasm to the nucleus of C2C12 myoblasts, concomitant to an up-regulation of the protein expression, occurs in parallel with the nuclear accumulation of myogenin. Moreover, we demonstrate that the LIM domain of smALP is essential for the nuclear translocation of the protein. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：628 / 633
页数：6
相关论文
共 50 条
  • [1] Cytoskeleton-associated protein tyrosine phosphorylation involved in induction of differentiation in mouse melanoma cells
    YAN Chunhong and HAN RuiInstitute of Materia Medica
    ChineseScienceBulletin, 1999, (04) : 335 - 339
  • [2] Cytoskeleton-associated protein tyrosine phosphorylation involved in induction of differentiation in mouse melanoma cells
    Yan, CH
    Han, R
    CHINESE SCIENCE BULLETIN, 1999, 44 (04): : 335 - 339
  • [3] The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation
    Pomies, Pascal
    Pashmforoush, Mohammad
    Vegezzi, Cristina
    Chien, Kenneth R.
    Auffray, Charles
    Beckerle, Mary C.
    MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (05) : 1723 - 1733
  • [4] A unique cytoskeleton-associated protein in Cryptococcus neoformans
    Gelli, Angie
    VIRULENCE, 2018, 9 (01) : 752 - 753
  • [5] Ankycorbin: a novel actin cytoskeleton-associated protein
    Peng, YF
    Mandai, K
    Sakisaka, T
    Okabe, N
    Yamamoto, Y
    Yokoyama, S
    Mizoguchi, A
    Shiozaki, H
    Monden, M
    Takai, Y
    GENES TO CELLS, 2000, 5 (12) : 1001 - 1008
  • [6] INDUCTION OF CYTOSKELETON-ASSOCIATED PROTEINS DURING DIFFERENTIATION OF HUMAN MYELOID LEUKEMIC-CELL LINES
    BERNAL, SD
    CHEN, LB
    CANCER RESEARCH, 1982, 42 (12) : 5106 - 5116
  • [7] A role for the cytoskeleton-associated protein palladin in neurite outgrowth
    Boukhelifa, M
    Parast, MM
    Valtschanoff, JG
    LaMantia, AS
    Meeker, RB
    Otey, CA
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (09) : 2721 - 2729
  • [8] DdLIM is a cytoskeleton-associated protein involved in the protrusion of lamellipodia in Dictyostelium
    Prassler, J
    Murr, A
    Stocker, S
    Faix, J
    Murphy, J
    Marriott, G
    MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (03) : 545 - 559
  • [9] Cortactin, a cytoskeleton-associated adaptor protein, in melanocytic tumor progression
    Xu, X.
    Spittle, C.
    Varella-Garcia, M.
    Edwards, R.
    Lessin, S.
    Wu, H.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 : S152 - S152
  • [10] Serum cytoskeleton-associated protein 4 as a biomarker for the diagnosis of hepatocellular carcinoma
    Wang, Yu
    Yu, Weixin
    He, Mingqing
    Huang, Yan
    Wang, Mingyue
    Zhu, Jinzhou
    ONCOTARGETS AND THERAPY, 2019, 12 : 359 - 364
12345