A convenient, rapid and eco-friendly synthesis of isoxazoline heterocyclic moiety containing bridge at 2°-amine as potential pharmacological agent

被引：46
|
作者：
Desai, J. T. [1 ]
Desai, C. K. [1 ]
Desai, K. R. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat W 395007, Gujarat, India
来源：
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2008年 / 5卷 / 01期
关键词：
coumarin; thiazole; isoxazole; microwave technique; antimicrobial activity evaluation;
D O I：
10.1007/BF03245817
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-Amino-4-(coumarin-3-yl)-thiazole (1) reacted with acetyl chloride gives compound (2) which on further refluxed with various aromatic aldehydes gives compound (3a-j). Thus obtained (3a-j) on further condensed with NH4OH.HCl using NaOH as a catalyst afforded isoxazoles (4a-j). All the synthesized compounds characterized on the basis of the IR, H-1 NMR, C-13 NMR and elemental analysis. All the compounds have been screened for antibacterial activity against bacteria (Gram + ve) & (Gram - ve) and antifungal activity.
引用
收藏
页码：67 / 73
页数：7
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