A convenient, rapid and eco-friendly synthesis of isoxazoline heterocyclic moiety containing bridge at 2°-amine as potential pharmacological agent

被引：46

作者：

Desai, J. T. ^{[1
]}

Desai, C. K. ^{[1
]}

Desai, K. R. ^{[1
]}

机构：

[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat W 395007, Gujarat, India

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2008年 / 5卷 / 01期

关键词：

coumarin; thiazole; isoxazole; microwave technique; antimicrobial activity evaluation;

D O I：

10.1007/BF03245817

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Amino-4-(coumarin-3-yl)-thiazole (1) reacted with acetyl chloride gives compound (2) which on further refluxed with various aromatic aldehydes gives compound (3a-j). Thus obtained (3a-j) on further condensed with NH4OH.HCl using NaOH as a catalyst afforded isoxazoles (4a-j). All the synthesized compounds characterized on the basis of the IR, H-1 NMR, C-13 NMR and elemental analysis. All the compounds have been screened for antibacterial activity against bacteria (Gram + ve) & (Gram - ve) and antifungal activity.

引用

页码：67 / 73

页数：7

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