Sex Hormone-Dependent Physiology and Diseases of Liver

被引：124

作者：

Kur, Paulina ^{[1
]}

Kolasa-Wolosiuk, Agnieszka ^{[1
]}

Misiakiewicz-Has, Kamila ^{[1
]}

Wiszniewska, Barbara ^{[1
]}

机构：

[1] Pomeranian Med Univ, Fac Med & Dent, Dept Histol & Embryol, Powst Wlkp 72, PL-70111 Szczecin, Poland

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2020年 / 17卷 / 08期

关键词：

gender-dependent liver failure; hepatic glucose metabolism; insulin resistance; type; 2; diabetes; metabolic syndrome; hepatic lipid metabolism; non-alcoholic fatty liver disease; cirrhosis; hepatocellular carcinoma; transgenic animal models; clinical cases; ESTROGEN-RECEPTOR-ALPHA; HEPATITIS-B-VIRUS; HEPATOCELLULAR-CARCINOMA CELLS; POLYCYSTIC-OVARY-SYNDROME; NF-KAPPA-B; INSULIN-RESISTANCE; ANDROGEN RECEPTOR; GENDER DISPARITY; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR RISK;

D O I：

10.3390/ijerph17082620

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Sexual dimorphism is associated not only with somatic and behavioral differences between men and women, but also with physiological differences reflected in organ metabolism. Genes regulated by sex hormones differ in expression in various tissues, which is especially important in the case of liver metabolism, with the liver being a target organ for sex hormones as its cells express estrogen receptors (ERs: ER alpha, also known as ESR1 or NR3A; ER beta; GPER (G protein-coupled ER, also known as GPR 30)) and the androgen receptor (AR) in both men and women. Differences in sex hormone levels and sex hormone-specific gene expression are mentioned as some of the main variations in causes of the incidence of hepatic diseases; for example, hepatocellular carcinoma (HCC) is more common in men, while women have an increased risk of autoimmune liver disease and show more acute liver failure symptoms in alcoholic liver disease. In non-alcoholic fatty liver disease (NAFLD), the distinction is less pronounced, but increased incidences are suggested among men and postmenopausal women, probably due to an increased tendency towards visceral fat accumulation.

引用

页数：26

共 166 条

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