An Overview of Synthesis and Biological Activity of Dihydropyrimidine Derivatives

被引：2

作者：

Dudhe, Anshu Chaudhary ^{[1
]}

Dudhe, Rupesh ^{[1
]}

Porwal, Omji ^{[2
]}

Katole, Gayatri ^{[1
]}

机构：

[1] GH Raisoni Univ, Sch Pharm, Chhindwara 480337, Madhya Pradesh, India

[2] Tishk Int Univ, Fac Pharm, Dept Pharm, Erbil, KRG, Iraq

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 05期

关键词：

Dihydropyrimidine; bignelli reaction; anticancer; antimicrobial; antiviral; synthesis; IN-VITRO ANTICANCER; ANTIMICROBIAL EVALUATION; ANTIFUNGAL ACTIVITY; BIGINELLI REACTION; INHIBITORS; SILICO; ALPHA;

D O I：

10.2174/1389557521666210920120457

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dihydropyrimidine derivatives are the most important scaffolds due to structural similarities with natural products; it is a heterocyclic compound. The chemistry of Dihydropyrimidine is a growing field. Various reaction schemes for the preparation of Dihydropyrimidines produce different biological effects and offer vast scope in the field of medicinal chemistry. This article's goal is to analyze the work that reported the recent chemistry and pharmacological activities of dihydropyrimidine derivatives.

引用

页码：701 / 728

页数：28

共 50 条

[21] Synthesis and biological activity of pyrazole derivatives
Li, ZM
Chen, HS
Zhao, WG
Zhang, K
Huang, XS
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 1997, 18 (11): : 1794 - 1799
[22] Biological Activity of Purpurogallin and its Derivatives
Silva, Iasmim L.
Camara, Celso A.
REVISTA VIRTUAL DE QUIMICA, 2021, 13 (01) : 207 - 221
[23] Synthesis, antifungal activity, and QSAR studies of 1,6-dihydropyrimidine derivatives
Rami, Chirag
Patel, Laxmanbhai
Patel, Chhaganbhai N.
Parmar, Jayshree P.
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2013, 5 (04): : 277 - 289
[24] A review on the synthesis and biological relevance of benzo[b]thiophene derivatives
Dhanya, T. M.
Krishna, G. Anjali
Savitha, D. P.
Shanty, A. A.
Divya, K. M.
Priya, Shenoi K.
Mohanan, P., V
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2023, 198 (04) : 283 - 299
[25] Synthesis and biological activity of flavane derivatives
He, L
Kong, EJ
Liu, YM
An, Y
Zhang, WS
Shi, DH
Tan, RX
CHINESE JOURNAL OF CHEMISTRY, 2006, 24 (03) : 401 - 408
[26] Synthesis of Some Novel Quinazolinone Derivatives with Anticipated Biological Activity
Marzouk, Magda I.
Shaker, Soheir A.
Farghaly, Thoraya A.
El-Hashash, Maher A.
Hussein, Shadia M.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (06) : 3331 - 3341
[27] Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine
Sharma, Ritu
Samadhiya, Pushkal
Srivastava, Savitri D.
Srivastava, Santosh K.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2012, 77 (01) : 17 - 26
[28] Part 2, Studies on the Synthesis of Quinolone Derivatives with their Biological Activity
Saxena, Nishtha
Shankhdhar, Swapnil
Kumar, Anil
Srivastava, Nivedita
CURRENT ORGANIC CHEMISTRY, 2024, 28 (03) : 185 - 212
[29] Synthesis, investigation of the new derivatives of dihydropyrimidines and determination of their biological activity
Maharramov, A. M.
Ramazanov, M. A.
Guliyeva, G. A.
Huseynzada, A. E.
Hasanova, U. A.
Shikhaliyev, N. G.
Eyvazova, G. M.
Hajiyeva, S. F.
Mamedov, I. G.
Aghayev, M. M.
JOURNAL OF MOLECULAR STRUCTURE, 2017, 1141 : 39 - 43
[30] Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors
Zhu, Lingjian
Cheng, Pengfei
Lei, Ning
Yao, Jianzhong
Sheng, Chunquan
Zhuang, Chunlin
Guo, Wei
Liu, Wenfeng
Zhang, Yongqiang
Dong, Guoqiang
Wang, Shengzhang
Miao, Zhenyuan
Zhang, Wannian
ARCHIV DER PHARMAZIE, 2011, 344 (11) : 726 - 734

← 1 2 3 4 5 →