Two New HPLC Methods, Assessed by GAPI, for Simultaneous Determination of Four Antipsychotics in Pharmaceutical Formulations: A Comparative Study

被引：8

作者：

Hameed, Eman A. Abdel ^{[1
]}

Abd El-Naby, Zaitona A. ^{[2
]}

El Gindy, Alaa ^{[2
]}

Zaitone, Sawsan A. ^{[3
]}

Alshaman, Reem ^{[4
]}

Saraya, Roshdy E. ^{[1
]}

Khairy, Gasser M. ^{[5
]}

机构：

[1] Port Said Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Port Fouad 42526, Egypt

[2] Suez Canal Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Ismailia 41522, Egypt

[3] Suez Canal Univ, Fac Pharm, Dept Pharmacol & Toxicol, Ismailia 41522, Egypt

[4] Univ Tabuk, Fac Pharm, Dept Pharmacol & Toxicol, Tabuk 71491, Saudi Arabia

[5] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41522, Egypt

来源：

SEPARATIONS | 2022年 / 9卷 / 08期

关键词：

quetiapine; aripiprazole; asenapine maleate; chlorpromazine; GAPI; HPLC; ASENAPINE MALEATE; AGENT ASENAPINE; LC METHOD; STABILITY; ARIPIPRAZOLE; VALIDATION; IMPURITIES; QUETIAPINE; BULK; QUANTIFICATION;

D O I：

10.3390/separations9080220

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Antipsychotics are widely used to treat various mental disorders. Combination therapies were approved by the FDA to treat manic states. Quetiapine fumarate, aripiprazole, asenapine maleate, and chlorpromazine HCl are frequently used for treatment of these disorders. Green analytical chemistry is primarily concerned with reducing waste generated during sample preparation or analysis. Green solvents, such as ethanol, are being used in HPLC as an alternative to acetonitrile. To this purpose, two new chromatographic methods were developed to determine these four drugs simultaneously in their bulk and pharmaceutical formulations. The greenness of both methods was assessed by the green analytical procedure index (GAPI)-one of them was found to be green ecofriendly, and the other had some environmental hazards (conventional)-and this helps laboratories to choose a method that suits their capabilities. The chromatographic separation for both methods was carried out on a Thermo (R) C18 column. The total separation times were about 11 min and 9 min for the green and the conventional methods, respectively. Using the Student's t-test and the F-ratio, there was no significant difference between the results of the two methods. These methods have been validated and successfully applied to the analysis of commercial pharmaceutical formulations. Our study could successfully be used in central quality control laboratories, which need a single analytical method to separate more than one compound with similar pharmacological action.

引用

页数：11