Lymph node fibroblastic reticular cells in health and disease

被引：230
作者：
Fletcher, Anne L. [1 ]
Acton, Sophie E. [2 ,3 ]
Knoblich, Konstantin [1 ]
机构：
[1] Univ Birmingham, Sch Immun & Infect, Inst Biomed Res, Edgbaston B15 2TT, W Midlands, England
[2] Canc Res UK London Res Inst, Immunobiol Lab, London WC2A 3LY, England
[3] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England
来源：
NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 06期
关键词：
MESENCHYMAL STEM-CELLS; STROMAL CELLS; DENDRITIC CELLS; T-CELLS; RECEPTOR-ALPHA; ANTIGEN; GROWTH; BETA; HOMEOSTASIS; PODOPLANIN;
D O I：
10.1038/nri3846
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) - immunologically specialized myofibroblasts found in lymphoid tissue - has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.
引用
收藏
页码：350 / 361
页数：12
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