Lymph node fibroblastic reticular cells in health and disease

被引：239

作者：

Fletcher, Anne L. ^{[1
]}

Acton, Sophie E. ^{[2
,3
]}

Knoblich, Konstantin ^{[1
]}

机构：

[1] Univ Birmingham, Sch Immun & Infect, Inst Biomed Res, Edgbaston B15 2TT, W Midlands, England

[2] Canc Res UK London Res Inst, Immunobiol Lab, London WC2A 3LY, England

[3] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 06期

关键词：

MESENCHYMAL STEM-CELLS; STROMAL CELLS; DENDRITIC CELLS; T-CELLS; RECEPTOR-ALPHA; ANTIGEN; GROWTH; BETA; HOMEOSTASIS; PODOPLANIN;

D O I：

10.1038/nri3846

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) - immunologically specialized myofibroblasts found in lymphoid tissue - has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.

引用

页码：350 / 361

页数：12

共 83 条

[1] Dendritic cells control fibroblastic reticular network tension and lymph node expansion [J].

Acton, Sophie E. ;

Farrugia, Aaron J. ;

Astarita, Jillian L. ;

Mourao-Sa, Diego ;

Jenkins, Robert P. ;

Nye, Emma ;

Hooper, Steven ;

van Blijswijk, Janneke ;

Rogers, Neil C. ;

Snelgrove, Kathryn J. ;

Rosewell, Ian ;

Moita, Luis F. ;

Stamp, Gordon ;

Turley, Shannon J. ;

Sahai, Erik ;

Reis e Sousa, Caetano .

NATURE, 2014, 514 (7523) :498-+

[2] Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 [J].

Acton, Sophie E. ;

Astarita, Jillian L. ;

Malhotra, Deepali ;

Lukacs-Kornek, Veronika ;

Franz, Bettina ;

Hess, Paul R. ;

Jakus, Zoltan ;

Kuligowski, Michael ;

Fletcher, Anne L. ;

Elpek, Kutlu G. ;

Bellemare-Pelletier, Angelique ;

Sceats, Lindsay ;

Reynoso, Erika D. ;

Gonzalez, Santiago F. ;

Graham, Daniel B. ;

Chang, Jonathan ;

Peters, Anneli ;

Woodruff, Matthew ;

Kim, Young-A. ;

Swat, Wojciech ;

Morita, Takashi ;

Kuchroo, Vijay ;

Carroll, Michael C. ;

Kahn, Mark L. ;

Wucherpfennig, Kai W. ;

Turley, Shannon J. .

IMMUNITY, 2012, 37 (02) :276-289

[3] Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth:: role of stromal cells in follicular lymphoma pathogenesis [J].

Ame-Thomas, Patricia ;

Maby-El Hajjami, Helene ;

Monvoisin, Celine ;

Jean, Rachel ;

Monnier, Delphine ;

Caulet-Maugendre, Sylvie ;

Guillaudeux, Thierry ;

Lamy, Thierry ;

Fest, Thierry ;

Tarte, Karin .

BLOOD, 2007, 109 (02) :693-702

[4] A chemokine-driven positive feedback loop organizes lymphoid follicles [J].

Ansel, KM ;

Ngo, VN ;

Hyman, PL ;

Luther, SA ;

Förster, R ;

Sedgwick, JD ;

Browning, JL ;

Lipp, M ;

Cyster, JG .

NATURE, 2000, 406 (6793) :309-314

[5] The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture [J].

Astarita, Jillian L. ;

Cremasco, Viviana ;

Fu, Jianxin ;

Darnell, Max C. ;

Peck, James R. ;

Nieves-Bonilla, Janice M. ;

Song, Kai ;

Kondo, Yuji ;

Woodruff, Matthew C. ;

Gogineni, Alvin ;

Onder, Lucas ;

Ludewig, Burkhard ;

Weimer, Robby M. ;

Carroll, Michael C. ;

Mooney, David J. ;

Xia, Lijun ;

Turley, Shannon J. .

NATURE IMMUNOLOGY, 2015, 16 (01) :75-+

[6] Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes [J].

Bajenoff, Marc ;

Egen, Jackson G. ;

Koo, Lily Y. ;

Laugier, Jean Pierre ;

Brau, Frederic ;

Glaichenhaus, Nicolas ;

Germain, Ronald N. .

IMMUNITY, 2006, 25 (06) :989-1001

[7] Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation [J].

Baptista, A P ;

Roozendaal, R. ;

Reijmers, R. M. ;

Koning, J. J. ;

Unger, W. W. ;

Greuter, M. ;

Keuning, E. D. ;

Molenaar, R. ;

Goverse, G. ;

Sneeboer, M. M. S. ;

den Haan, J. M. M. ;

Boes, M. ;

Mebius, R. E. .

ELIFE, 2014, 3 :1-18

[8] CLEC-2 is required for development and maintenance of lymph nodes [J].

Benezech, Cecile ;

Nayar, Saba ;

Finney, Brenda A. ;

Withers, David R. ;

Lowe, Kate ;

Desanti, Guillaume E. ;

Marriott, Clare L. ;

Watson, Steve P. ;

Caamano, Jorge H. ;

Buckley, Christopher D. ;

Barone, Francesca .

BLOOD, 2014, 123 (20) :3200-3207

[9] Lymphotoxin-β Receptor Signaling through NF-κB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells [J].

Benezech, Cecile ;

Mader, Emma ;

Desanti, Guillaume ;

Khan, Mahmood ;

Nakamura, Kyoko ;

White, Andrea ;

Ware, Carl F. ;

Anderson, Graham ;

Caamano, Jorge H. .

IMMUNITY, 2012, 37 (04) :721-734

[10] Ontogeny of Stromal Organizer Cells during Lymph Node Development [J].

Benezech, Cecile ;

White, Andrea ;

Mader, Emma ;

Serre, Karine ;

Parnell, Sonia ;

Pfeffer, Klaus ;

Ware, Carl F. ;

Anderson, Graham ;

Caamano, Jorge H. .

JOURNAL OF IMMUNOLOGY, 2010, 184 (08) :4521-4530

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