Neuroenergetics: Astrocytes Have a Sweet Spot for Glucose

被引:20
作者
Pellerin, Luc [1 ,2 ]
机构
[1] Univ Lausanne, Dept Physiol, Lausanne, Switzerland
[2] Univ Bordeaux, CNRS, Labex TRAIL IBIO, Ctr Resonance Magnet Syst Biol,UMR5536, F-33076 Bordeaux, France
关键词
LACTATE; NEURONS; TRANSPORTERS;
D O I
10.1016/j.cub.2018.09.042
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Astrocytes are polarized cells that are known to take up glucose while delivering lactate, not glucose, for neuronal use. A new study suggests how astrocytes could facilitate glucose uptake, storage and funneling at energy-requiring sites through a privileged intracellular route.
引用
收藏
页码:R1258 / R1260
页数:4
相关论文
共 20 条
[1]   Small is fast: astrocytic glucose and lactate metabolism at cellular resolution [J].
Barros, L. F. ;
San Martin, A. ;
Sotelo-Hitschfeld, T. ;
Lerchundi, R. ;
Fernandez-Moncada, I. ;
Ruminot, I. ;
Gutierrez, R. ;
Valdebenito, R. ;
Ceballo, S. ;
Alegria, K. ;
Baeza-Lehnert, F. ;
Espinoza, D. .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2013, 7
[2]   Three-dimensional Ca2+ imaging advances understanding of astrocyte biology [J].
Bindocci, Erika ;
Savtchouk, Iaroslav ;
Liaudet, Nicolas ;
Becker, Denise ;
Carriero, Giovanni ;
Volterra, Andrea .
SCIENCE, 2017, 356 (6339)
[3]   Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain [J].
Bittar, PG ;
Charnay, Y ;
Pellerin, L ;
Bouras, C ;
Magistretti, PJ .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (06) :1079-1089
[4]   Lactate is a preferential oxidative energy substrate over glucose for neurons in culture [J].
Bouzier-Sore, AK ;
Voisin, P ;
Canioni, P ;
Magistretti, TJ ;
Pellerin, T .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (11) :1298-1306
[5]   Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex [J].
Chuquet, Julien ;
Quilichini, Pascale ;
Nimchinsky, Esther A. ;
Buzsaki, Gyoergy .
JOURNAL OF NEUROSCIENCE, 2010, 30 (45) :15298-15303
[6]   GLYCOGEN IN ASTROCYTES - POSSIBLE FUNCTION AS LACTATE SUPPLY FOR NEIGHBORING CELLS [J].
DRINGEN, R ;
GEBHARDT, R ;
HAMPRECHT, B .
BRAIN RESEARCH, 1993, 623 (02) :208-214
[7]  
Kacem K, 1998, GLIA, V23, P1
[8]   In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons [J].
Machler, Philipp ;
Wyss, Matthias T. ;
Elsayed, Maha ;
Stobart, Jillian ;
Gutierrez, Robin ;
von Faber-Castell, Alexandra ;
Kaelin, Vincens ;
Zuend, Marc ;
San Martin, Alejandro ;
Romero-Gomez, Ignacio ;
Baeza-Lehnert, Felipe ;
Lengacher, Sylvain ;
Schneider, Bernard L. ;
Aebischer, Patrick ;
Magistretti, Pierre J. ;
Felipe Barros, L. ;
Weber, Bruno .
CELL METABOLISM, 2016, 23 (01) :94-102
[9]   NEUROTRANSMITTERS REGULATE ENERGY-METABOLISM IN ASTROCYTES - IMPLICATIONS FOR THE METABOLIC TRAFFICKING BETWEEN NEURAL CELLS [J].
MAGISTRETTI, PJ ;
SORG, O ;
YU, NC ;
MARTIN, JL ;
PELLERIN, L .
DEVELOPMENTAL NEUROSCIENCE, 1993, 15 (3-5) :306-312
[10]   THE HUMAN BLOOD-BRAIN-BARRIER GLUCOSE-TRANSPORTER (GLUT1) IS A GLUCOSE-TRANSPORTER OF GRAY-MATTER ASTROCYTES [J].
MORGELLO, S ;
USON, RR ;
SCHWARTZ, EJ ;
HABER, RS .
GLIA, 1995, 14 (01) :43-54