Tamoxifen inhibits phorbol ester-induced reactive nitrogen intermediate production by U937 cells

被引：0
|
作者：
Martin, JHJ
Alalami, O
机构：
来源：
ONCOLOGY REPORTS | 1996年 / 3卷 / 05期
关键词：
tamoxifen; phorbol ester; U937; cells; nitric oxide;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Phorbol 12-myristate 13-acetate (PMA) enhanced nitrite production by U937 cells. During a 6-day treatment of U937 cells with PMA (200 nM-1000 nM) there was a significant increase (p<0.001) in NO2- secreted into the culture medium. Treatment of the same cells with tamoxifen (10(-10) M -10(-6) M) had no effect on nitrite production. However, tamoxifen was able to significantly (p<0.05) down-regulate PMA-enhanced nitrite production by U937 cells.
引用
收藏
页码：935 / 937
页数：3
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