Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological Consequences

被引：76

作者：

Donovan, Meg L. ^{[1
]}

Schultz, Thomas E. ^{[1
]}

Duke, Taylor J. ^{[1
]}

Blumenthal, Antje ^{[1
]}

机构：

[1] Univ Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

基金：

英国医学研究理事会;

关键词：

Mycobacterium tuberculosis; type I interferon; innate immune signaling; pattern recognition receptors; immune responses; cytokines; patients; mouse models; TOLL-LIKE RECEPTORS; RESISTANT PULMONARY TUBERCULOSIS; ESX-1 SECRETION SYSTEM; CHRONIC HEPATITIS-C; T-CELL STIMULATION; CYCLIC DI-GMP; MYCOBACTERIUM-TUBERCULOSIS; IMMUNE-RESPONSE; IL-1-BETA PRODUCTION; ACTIVE TUBERCULOSIS;

D O I：

10.3389/fimmu.2017.01633

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tuberculosis (TB) remains a major global health threat. Urgent needs in the fight against TB include improved and innovative treatment options for drug-sensitive and -resistant TB as well as reliable biological indicators that discriminate active from latent disease and enable monitoring of treatment success or failure. Prominent interferon (IFN) inducible gene signatures in TB patients and animal models of Mycobacterium tuberculosis infection have drawn significant attention to the roles of type I IFNs in the host response to mycobacterial infections. Here, we review recent developments in the understanding of the innate immune pathways that drive type I IFN responses in mycobacteria-infected host cells and the functional consequences for the host defense against M. tuberculosis, with a view that such insights might be exploited for the development of targeted host-directed immunotherapies and development of reliable biomarkers.

引用

页数：16

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