What is the relationship between risk factor reduction and degree of weight loss?

被引：81

作者：

Van Gaal, LF ^{[1
]}

Mertens, IL ^{[1
]}

Ballaux, D ^{[1
]}

机构：

[1] Univ Antwerp Hosp, Fac Med UA, Dept Diabetol Metab & Nutr, Antwerp, Belgium

来源：

EUROPEAN HEART JOURNAL SUPPLEMENTS | 2005年 / 7卷 / 0L期

关键词：

cardiovascular disease; cholesterol; diabetes prevention; lifestyle prevention; obesity; weight loss;

D O I：

10.1093/eurheartj/sui082

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Moderate weight toss achieved through lifestyle interventions positively impacts on a number of metabolic and cardiovascular risk factors. Clinical studies have shown that sustained moderate weight loss towers blood pressure, improves glucose control, and improves dyslipidaemia as well as inflammatory, haemostatic, and fibrinolytic factors. In addition, it is associated with the prevention of progression to Type 2 diabetes in at-risk subjects. Furthermore, increasing physical fitness is associated with increases in HDL cholesterol and reductions in all-cause mortality. However, there is, as yet, only indirect evidence that modification of risk factors through weight loss will reduce mortality.

引用

页码：L21 / L26

页数：6

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