Chemical constituents of Menispermum dauricum

AIM: To study the chemical constituents of Menispermum dauricum DC. METHODS: Compounds were isolated by repeated chromatography on silica gel and Sephadex LH-20. The structures were identified by spectral analysis and comparison with literature data. RESULTS: Eleven compounds were obtained and identified as dauricumine (1), dauricumidine (2), acutuminine (3), physcion (4), blumenol C (5), blumenolA (6), N-trans feruloyltyramine (7), vanillin (8), beta-sitostenone (9), beta-sitosterol (10), and daucosterol (11). CONCLUSION: All compounds were known, but isolated from the plant for first time. Compounds 1 and 2 were chlorine-containing alkaloids obtained from natural source for the first time. The stereochemistry of 3 was determined for first time.