Genes, Brains, and Behavior: Imaging Genetics for Neuropsychiatric Disorders

被引：14

作者：

Arslan, Ayla ^{[1
,2
]}

机构：

[1] Int Univ Sarajevo, Fac Engn & Nat Sci, Genet & Bioengn Dept, Sarajevo, Bosnia & Herceg

[2] Uskudar Univ, Dept Mol Biol & Genet, Fac Engn & Nat Sci, Istanbul, Turkey

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2015年 / 27卷 / 02期

关键词：

GENOME-WIDE ASSOCIATION; SEROTONIN TRANSPORTER GENE; OXYTOCIN RECEPTOR OXTR; COMMON VARIANTS; QUANTITATIVE TRAIT; NEURAL MECHANISMS; PSYCHIATRIC-DISORDERS; ALZHEIMERS-DISEASE; FUNCTIONAL IMPACT; SOCIAL HIERARCHY;

D O I：

10.1176/appi.neuropsych.13080185

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The majority of neuropsychiatric disorders show a strong degree of heritability, yet little is known about molecular factors involved in the pathophysiology of diseases like schizophrenia. After a brief historical introduction into the current understanding of neuropsychiatric disorders, the aim of this study is to discuss imaging genetics as a strategy to explore the pathophysiology of neuropsychiatric disorders. The candidate gene approach of imaging genetics is used for validation/replication studies of genes, whereas the hypothesis-free, noncandidate gene approach appears to be a tool for gene discovery. Besides, integration of environmental factors into neuroimaging begins to converge on neuroimaging studies of genetic variation. In the light of data from other avenues such as animal experimentation, these developments show a model of interdisciplinary research, which may lead to identifying markers for neuropsychiatric disorders.

引用

页码：81 / 92

页数：12

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