Evidence for epistatic gene interactions between growth factor genes in stroke outcome

被引：17

作者：

Manso, H. ^{[1
,2
,3
]}

Krug, T. ^{[2
,4
]}

Sobral, J. ^{[2
,4
]}

Albergaria, I. ^{[1
]}

Gaspar, G. ^{[1
]}

Ferro, J. M. ^{[4
,5
]}

Oliveira, S. A. ^{[2
,4
]}

Vicente, A. M. ^{[1
,2
,3
]}

机构：

[1] Inst Nacl Saude Dr Ricardo Jorge INSA, DPSDC, Lisbon, Portugal

[2] IGC, Oeiras, Portugal

[3] Ctr Biodivers Funct & Integrat Genom BIOFIG, Lisbon, Portugal

[4] Univ Lisbon, Fac Med, Inst Mol Med, P-1699 Lisbon, Portugal

[5] Hosp Santa Maria, Serv Neurol, Lisbon, Portugal

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2012年 / 19卷 / 08期

关键词：

epidemiology; genetic association study; stroke; MULTIFACTOR-DIMENSIONALITY REDUCTION; FOCAL CEREBRAL-ISCHEMIA; NEUROGENESIS; ANGIOGENESIS; VEGF;

D O I：

10.1111/j.1468-1331.2011.03625.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: Growth factors are thought to modulate neurological function in stroke recovery through effects in angiogenesis, neurogenesis, and neuroprotection. Methods: We tested the association of variants in the brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) genes, and epistatic interactions between them, with functional outcome in a sample of 546 stroke patients. Results: While none of the tested genes was independently associated with stroke outcome, two significant genegene interaction models were identified. One model combined one BDNF and three FGF2 markers, with a global odds ratio (OR) (95% confidence interval [CI]) of 4.15 [2.866.04]. The second model included one FGF2 and two VEGFA markers with a global OR [95% CI] = 2.54 [1.763.67]. Conclusions: The results provide evidence for gene interactions in stroke outcome, highlighting the complexity of the recovery mechanisms after a stroke event.

引用

页码：1151 / 1153

页数：3

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