An enantio- and stereocontrolled synthesis of (-)-mycestericin E via cinchona alkaloid-catalyzed asymmetric Baylis-Hillman reaction

被引：133

作者：

Iwabuchi, Y ^{[1
]}

Furukawa, M ^{[1
]}

Esumi, T ^{[1
]}

Hatakeyama, S ^{[1
]}

机构：

[1] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 19期

关键词：

D O I：

10.1039/b106471c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new enantiocontrolled synthesis of a potent immunosuppressant (-)-mycestericin E has been accomplished by using cinchona alkaloid-catalyzed asymmetric Baylis-Hillman reaction of an aldehyde with 1,1,1,3,3,3-hexafluoroisopropyl acrylate and Lewis acid-promoted cyclisation of an epoxytrichloroacetimidate as the key steps.

引用

页码：2030 / 2031

页数：2

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