Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates

被引：199
作者：
Parsons, Andrew T. [1 ]
Senecal, Todd D. [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 12期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
fluorine; homogeneous catalysis; iron; trifluoromethylation; COPPER-CATALYZED TRIFLUOROMETHYLATION; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; ALLYLIC TRIFLUOROMETHYLATION; ARYL FLUORIDES; BORONIC ACIDS; REAGENT; PERFLUOROALKYLATION; ORGANOCATALYSIS;
D O I：
10.1002/anie.201108267
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Exchanging BF 3 by CF 3: The title reaction proceeds under exceedingly mild reaction conditions and provides 2-arylvinyl- and 2-heteroarylvinyl-substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalation of the RBF 3K species to the iron catalyst. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2947 / 2950
页数：4
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