Importance of clonal hematopoiesis for hematologic neoplasms

被引：0

作者：

Goetze, Katharina S. ^{[1
]}

Lengerke, Claudia ^{[2
]}

机构：

[1] Tech Univ Munich, Med Klin & Poliklin Hamatol & Internist Onkol 3, Ismaninger Str 22, D-81675 Munich, Germany

[2] Univ Klinikum Tubingen, Innere Med Hamatol Onkol Klin Immunol & Rheumat 2, Tubingen, Germany

来源：

INNERE MEDIZIN | 2022年 / 63卷 / 11期

关键词：

Clonal hematopoiesis of indeterminate potential; Hematologic neoplasms; transformation rate; Somatic mutations; Hematopoietic stem cells; Risk factors; SOMATIC MUTATIONS; THERAPY; BLOOD; PPM1D; RISK; EVOLUTION; ANEMIA; DNMT3A; COMMON; TP53;

D O I：

10.1007/s00108-022-01401-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Clonal hematopoiesis of indeterminate potential (CHIP) is a fairly newly described phenomenon characterized by myeloid cancer-associated somatic mutations detectable in the peripheral blood of individuals without evidence of hematologic disease. Individuals with CHIP have a significantly increased risk of developing a hematologic malignancy, although the overall rate of transformation is low. Objective We review the current state of knowledge on causes of clonal expansion of blood cells as well as identifiable risk factors for progression to overt hematologic malignancy. Results and conclusion CHIP is considered a premalignant state and predisposes to the development of hematologic malignancy. Because the overall rate of transformation is low, clear identification and subsequent monitoring of those CHIP individuals at a higher risk is of paramount importance. In the future, prospective studies evaluating preventive and/or preemptive therapeutic strategies may aid in avoiding progression to blood cancer in individuals with CHIP.

引用

页码：1107 / 1114

页数：8

共 57 条

[1] An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis [J].

Abegunde, Samuel O. ;

Buckstein, Rena ;

Wells, Richard A. ;

Rauh, Michael J. .

EXPERIMENTAL HEMATOLOGY, 2018, 59 :60-65

[2] Prediction of acute myeloid leukaemia risk in healthy individuals [J].

Abelson, Sagi ;

Collord, Grace ;

Ng, Stanley W. K. ;

Weissbrod, Omer ;

Cohen, Netta Mendelson ;

Niemeyer, Elisabeth ;

Barda, Noam ;

Zuzarte, Philip C. ;

Heisler, Lawrence ;

Sundaravadanam, Yogi ;

Luben, Robert ;

Hayat, Shabina ;

Wang, Ting Ting ;

Zhao, Zhen ;

Cirlan, Julia ;

Pugh, Trevor J. ;

Soave, David ;

Ng, Karen ;

Latimer, Calli ;

Hardy, Claire ;

Raine, Keiran ;

Jones, David ;

Hoult, Diana ;

Britten, Abigail ;

McPherson, John D. ;

Johansson, Mattias ;

Mbabaali, Faridah ;

Eagles, Jenna ;

Millers, Jessica K. ;

Pasternack, Danielle ;

Timms, Lee ;

Krzyzanowski, Paul ;

Awadalla, Philip ;

Costa, Rui ;

Segal, Eran ;

Bratman, Scott, V ;

Beer, Philip ;

Behjati, Sam ;

Martincorena, Inigo ;

Wang, Jean C. Y. ;

Bowles, Kristian M. ;

Ramon Quiros, J. ;

Karakatsani, Anna ;

La Vecchia, Carlo ;

Trichopoulou, Antonia ;

Salamanca-Fernandez, Elena ;

Huerta, Jose M. ;

Barricarte, Aurelio ;

Travis, Ruth C. ;

Tumino, Rosario .

NATURE, 2018, 559 (7714) :400-+

[3] The Association between Clonal Hematopoiesis and Gout [J].

Agrawal, Mridul ;

Niroula, Abhishek ;

Cunin, Pierre ;

McConkey, Marie ;

Kim, Peter G. ;

Wong, Waihay J. ;

Weeks, Lachelle D. ;

Lin, Amy E. ;

Miller, Peter G. ;

Gibson, Christopher J. ;

Sekar, Aswin ;

Neuberg, Donna S. ;

Bick, Alexander G. ;

Natarajan, Pradeep ;

Nigrovic, Peter A. ;

Rao, Deepak A. ;

Ebert, Benjamin L. .

BLOOD, 2021, 138

[4] Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis [J].

Arends, Christopher Maximilian ;

Weiss, Marlene ;

Christen, Friederike ;

Eulenberg-Gustavus, Claudia ;

Rousselle, Anthony ;

Kettritz, Ralph ;

Eckardt, Kai-Uwe ;

Chan, Willy ;

Hoyer, Kaja ;

Frick, Mareike ;

Bullinger, Lars ;

Bieringer, Markus ;

Schreiber, Adrian ;

Damm, Frederik .

HAEMATOLOGICA, 2020, 105 (06) :E264-E267

[5] Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [J].

Avagyan, S. ;

Henninger, J. E. ;

Mannherz, W. P. ;

Mistry, M. ;

Yoon, J. ;

Yang, S. ;

Weber, M. C. ;

Moore, J. L. ;

Zon, L., I .

SCIENCE, 2021, 374 (6568) :768-+

[6] Cancer therapy shapes the fitness landscape of clonal hematopoiesis [J].

Bolton, Kelly L. ;

Ptashkin, Ryan N. ;

Gao, Teng ;

Braunstein, Lior ;

Devlin, Sean M. ;

Kelly, Daniel ;

Patel, Minal ;

Berthon, Antonin ;

Syed, Aijazuddin ;

Yabe, Mariko ;

Coombs, Catherine C. ;

Caltabellotta, Nicole M. ;

Walsh, Mike ;

Offit, Kenneth ;

Stadler, Zsofia ;

Mandelker, Diana ;

Schulman, Jessica ;

Patel, Akshar ;

Philip, John ;

Bernard, Elsa ;

Gundem, Gunes ;

Ossa, Juan E. Arango ;

Levine, Max ;

Martinez, Juan S. Medina ;

Farnoud, Noushin ;

Glodzik, Dominik ;

Li, Sonya ;

Robson, Mark E. ;

Lee, Choonsik ;

Pharoah, Paul D. P. ;

Stopsack, Konrad H. ;

Spitzer, Barbara ;

Mantha, Simon ;

Fagin, James ;

Boucai, Laura ;

Gibson, Christopher J. ;

Ebert, Benjamin L. ;

Young, Andrew L. ;

Druley, Todd ;

Takahashi, Koichi ;

Gillis, Nancy ;

Ball, Markus ;

Padron, Eric ;

Hyman, David M. ;

Baselga, Jose ;

Norton, Larry ;

Gardos, Stuart ;

Klimek, Virginia M. ;

Scher, Howard ;

Bajorin, Dean .

NATURE GENETICS, 2020, 52 (11) :1219-+

[7] Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies [J].

Bowman, Robert L. ;

Busque, Lambert ;

Levine, Ross L. .

CELL STEM CELL, 2018, 22 (02) :157-170

[8] DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions [J].

Buscarlet, Manuel ;

Provost, Sylvie ;

Zada, Yassamin Feroz ;

Barhdadi, Amina ;

Bourgoin, Vincent ;

Lepine, Guylaine ;

Mollica, Luigina ;

Szuber, Natasha ;

Dube, Marie-Pierre ;

Busque, Lambert .

BLOOD, 2017, 130 (06) :753-762

[9] Clonal hematopoiesis: mechanisms driving dominance of stem cell clones [J].

Challen, Grant A. ;

Goodell, Margaret A. .

BLOOD, 2020, 136 (14) :1590-1598

[10] Enriched clonal hematopoiesis in seniors with dietary vitamin C inadequacy [J].

Chen, Jiaqi ;

Nie, Daijing ;

Wang, Xinyu ;

Wang, Lei ;

Wang, Fang ;

Zhang, Yang ;

Chen, Xue ;

Cao, Panxiang ;

Li, Minghua ;

Ma, Xiaoli ;

Yu, Tongtong ;

Zhou, Xiaosu ;

Tian, Wenjun ;

Zhang, Yu ;

Li, Yu ;

Tan, Yincheng ;

Sun, Wenli ;

Fang, Jiancheng ;

Liu, Mingyue ;

Xu, Wen ;

Liu, Hongxing .

CLINICAL NUTRITION ESPEN, 2021, 46 :179-184

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