The growth peculiarities of human and mouse tumour explants and isolated tumour cells under the influence of immunomodulators different nature

被引：0

作者：

Berezhnaya, NM ^{[1
]}

Kovalchuk, EV ^{[1
]}

Denisevich, TV ^{[1
]}

Osipova, EV ^{[1
]}

Konovalenko, VF ^{[1
]}

Tolstopyatov, BA ^{[1
]}

Trembach, AM ^{[1
]}

Protsik, VS ^{[1
]}

Vorobjova, LI ^{[1
]}

Pinchouk, VG ^{[1
]}

Yakshibayeva, YR ^{[1
]}

机构：

[1] MINIST PUBL HLTH UKRAINE,UKRAINIAN RES INST ONCOL & RADIOL,UA-252022 KIEV,UKRAINE

来源：

EXPERIMENTAL ONCOLOGY | 1996年 / 18卷 / 03期

关键词：

immunomodulators; tumour explants and cells; spheroid formation;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of immunomodulators of different nature (rIL-2, thymalin, levamisole, interferon-alpha) on the growth of human and mouse tumour explants and isolated tumour cells has been investigated. It was shown, that immunomodulators exert different effects on the growth of tumour explants and isolated cells depending on the nature, doses of immunomodulators, and particular model of tumour growth used in the experiments. Comparative analysis of immunomodulators' effects showed that rIL-2 has the greatest identity of action on the tumour cells and explants in various model systems. Revealed differences of immunomodulators effects testify to a necessity to determine individual sensitivity of human tumors to immunomodulators, irrespective of their nature.

引用

页码：244 / 250

页数：7

共 27 条

[1] MECHANISM OF SYNERGY OF LEVAMISOLE AND FLUOROURACIL - INDUCTION OF HUMAN-LEUKOCYTE ANTIGEN CLASS-I IN A COLORECTAL-CANCER CELL-LINE [J].

ABDALLA, EE ;

BLAIR, GE ;

JONES, RA ;

SUELING, HM ;

JOHNSTON, D .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (07) :489-496

[2]

Amery WK, 1984, IMMUNE MODULATION AG, P383

[3] CYTOKINE THERAPY OF NEOPLASTIC AND INFLAMMATORY DISEASE [J].

AULITZKY, WE ;

HUBER, C ;

PESCHEL, C .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1993, 101 (03) :221-226

[4]

BARTON DPJ, 1994, ANTICANCER RES, V14, P761

[5]

BEREZHNAYA N M, 1987, Immunologiya, P66

[6]

BEREZHNAYA NM, 1986, EKSP ONKOL, V8, P50

[7]

BEREZHNAYA NM, 1994, EKSP ONKOL, V16, P40

[8]

BEREZHNAYA NM, 1994, EKSP ONKOL, V16, P181

[9]

BEREZHNAYA NM, 1992, INTERLEIKIN 2 ZLOKAC

[10]

CHEKNEV SB, 1994, B EKSP BIOL MED, V12, P619

← 1 2 3 →