Insights on the molecular targets of cardiotoxicity induced by anticancer drugs: A systematic review based on proteomic findings

被引：21

作者：

Branda, Sofia Reis ^{[1
,2
,4
]}

Carvalho, Felix ^{[1
,2
]}

Amado, Francisco ^{[3
]}

Ferreira, Rita ^{[2
,3
]}

Costa, Vera Marisa ^{[1
,4
]}

机构：

[1] Univ Porto, Inst Hlth & Bioecon, Fac Pharm, Associate Lab i4HB, P-4050313 Porto, Portugal

[2] Univ Porto, Fac Pharm, Dept Biol Sci, Appl Mol Biosci Unit,UCIBIO,REQUIMTE,Lab Toxicol, Rua Jorge Viterbo Ferreira 28, P-4050313 Porto, Portugal

[3] Univ Aveiro, Dept Chem, LAQV, REQUIMTE, P-3810193 Aveiro, Portugal

[4] Univ Porto, Fac Farm, Lab Toxicol, UCIBIO,REQUIMTE, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2022年 / 134卷

关键词：

Proteome modulation; Molecular pathways; Cardiotoxicity; Anticancer agents; Chemotherapy; INDUCED HEART-FAILURE; RANDOMIZED PHASE-3; FUNCTIONAL ROLES; REDOX PROTEOMICS; BETA-OXIDATION; BREAST-CANCER; CYTOCHROME-C; DOXORUBICIN; IDENTIFICATION; ADRIAMYCIN;

D O I：

10.1016/j.metabol.2022.155250

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several anticancer agents have been associated with cardiac toxic effects. The currently proposed mechanisms to explain cardiotoxicity differ among anticancer agents, but in fact, the specific modulation is not completely elucidated. Thus, this systematic review aims to provide an integrative perspective of the molecular mechanisms underlying the toxicity of anticancer agents on heart muscle while using a high-throughput technology, mass spectrometry (MS)-based proteomics. A literature search using PubMed database led to the selection of 27 studies, of which 13 reported results exclusively on animal models, 13 on cardiomyocyte-derived cell lines and only one included both animal and a cardiomyocyte line. The reported anticancer agents were the proteasome

引用

页数：29

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