Rapid determination of telmisartan in pharmaceutical preparations and serum by linear sweep polarography

被引：23
作者：
Xu, MT
Song, JF [1 ]
Liang, YD
机构：
[1] NW Univ Xian, Inst Analyt Sci, Xian 710069, Peoples R China
[2] Shongqiu Normal Coll, Dept Chem, Shangqiu 476000, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 34卷 / 03期
基金：
中国国家自然科学基金;
关键词：
telmisartan; catalytic hydrogen wave; linear sweep polarography; pharmaceutical analysis;
D O I：
10.1016/S0731-7085(03)00550-8
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The polarographic behaviors of telmisartan (TE) are investigated in 0.8mol/l NH3.H2O-NH4Cl (pH = 8.9) supporting electrolyte. The results demonstrated that the reduction peak is obtained at ca. -1.30V, which corresponds to a catalytic hydrogen wave. Based on the catalytic hydrogen wave, a novel method has been developed for the determination of telmisartan by linear sweep polarography. Calibration curve is linear in the range 2.0 x 10(-7) to 3.0 x 10(-6) mol/l and the detection limit is 1.0 X 10(-7) mol/l. The proposed method is applied to the rapid determination of the telmisartan in capsule forms and biological sample without pre-separation. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：681 / 687
页数：7
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