ANALYSIS OF THE ASSOCIATION BETWEEN SH2B1 CHR16.28884655 AND TYPE 2 DIABETES

被引：0
|
作者：
Liu, Jingjin [1 ]
Cao, Renjun [2 ]
Li, Dewei [1 ]
Miao, Fang [1 ]
Yang, Ping An [1 ]
He, Hui [1 ]
Yu, Han [1 ]
Zhang, Xiang [1 ]
Qin, Jie [1 ]
Yang, Yanlan [1 ]
机构：
[1] Shanxi Prov Peoples Hosp, Endocrinol, Taiyuan, Peoples R China
[2] Affiliated Changzhi Med Coll, Endocrinol, Heji Hosp, Changzhi, Peoples R China
来源：
CLINICAL AND INVESTIGATIVE MEDICINE | 2022年 / 45卷 / 04期
关键词：
VARIANTS; OBESITY;
D O I：
10.25011/cim.v45i4.39273
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Purpose: To determine correlation between genetic susceptibility of type 2 diabetes mellitus (T2DM) and Src homology 2 B adapter protein 1 (SH2B1) gene polymorphism in a diabetic population. Methods: A total of 111 T2DM patients (DM group) and 34 healthy controls (NC group) from Shanxi Provincial People's Hospital were included in this study. Exon 9 of the SH2B1 gene was detected using the Sanger sequencing method, and the relationship between SH2B1 gene polymorphism and diabetes was analyzed.Results: Comparison of the data between the two groups showed that the values of TG, the updated HOMA of insulin resistance (HOMA2-IR), weight, body mass index, waist circumference, fasting blood glucose and fasting insulin levels of the DM group were higher than those of the NC group (P < 0.05). The HOMA2 insulin sensitivity (%S) of the DM group was lower than that of the NC group (P < 0.05). Sequencing analysis revealed that the following five single nucleotide polymorphisms in exon 9 of SH2B1 may be related to T2DM: rs181578610, rs550079240, chr16.28884655, chr16.28884659 and chr16.28884831. Among them, chr16.28884655 was found to be significantly related to diabetes; this site, located on the NM_015503 exon, was related to TG, LDL-C and waist circumference. Conclusion: The SH2B1 gene locus chr16.28884655 was found to be significantly related to genetic susceptibility to T2DM.
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页码：E33 / E38
页数：6
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