共 57 条
Molecular Insight into the Binding of Astilbin with Human Serum Albumin and Its Effect on Antioxidant Characteristics of Astilbin
被引:11
作者:

Han, Xiangyu
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机构:
Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China

Sun, Jing
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Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China

Niu, Tianmei
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Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China

Mao, Beibei
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Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China

Gao, Shijie
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机构:
Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China

Zhao, Pan
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机构:
Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China

Sun, Linlin
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h-index: 0
机构:
Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
机构:
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
astilbin;
human serum albumin;
multi-spectroscopic;
molecular docking;
molecular dynamics simulation;
anti-oxidation;
DYNAMIC SIMULATION;
DOCKING;
DRUG;
D O I:
10.3390/molecules27144487
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Astilbin is a dihydroflavonol glycoside identified in many natural plants and functional food with promising biological activities which is used as an antioxidant in the pharmaceutical and food fields. This work investigated the interaction between astilbin and human serum albumin (HSA) and their effects on the antioxidant activity of astilbin by multi-spectroscopic and molecular modeling studies. The experimental results show that astilbin quenches the fluorescence emission of HSA through a static quenching mechanism. Astilbin and HSA prefer to bind at the Site I position, which is mainly maintained by electrostatic force, hydrophobic and hydrogen bonding interactions. Multi-spectroscopic and MD results indicate that the secondary structure of HSA could be changed because of the interaction of astilbin with HSA. DPPH radical scavenging assay shows that the presence of HSA reduces the antioxidant capacity of astilbin. The explication of astilbin-HSA binding mechanism will provide insights into clinical use and resource development of astilbin in food and pharmaceutical industries.
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页数:19
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[J].
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;
Le Scanff, Marie
;
Waffo-Teguo, Pierre
;
Marchal, Axel
.
FOOD CHEMISTRY,
2021, 352

论文数: 引用数:
h-index:
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Le Scanff, Marie
论文数: 0 引用数: 0
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[12]
Development and validation of an LC-FTMS method for quantifying natural sweeteners in wine
[J].
Fayad, Syntia
;
Cretin, Blandine N.
;
Marchal, Axel
.
FOOD CHEMISTRY,
2020, 311

论文数: 引用数:
h-index:
机构:

Cretin, Blandine N.
论文数: 0 引用数: 0
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Univ Bordeaux, ISVV, Unite Rech OENOLOGIE, INRA,ISVV,EA 5477,USC 1366, F-33882 Villenave Dornon, France Univ Bordeaux, ISVV, Unite Rech OENOLOGIE, INRA,ISVV,EA 5477,USC 1366, F-33882 Villenave Dornon, France

论文数: 引用数:
h-index:
机构:
[13]
Stabilization of a potential anticancer thiosemicarbazone derivative in Sudlow site I of human serum albumin: In vitro spectroscopy coupled with molecular dynamics simulation
[J].
Ganorkar, Kapil
;
Mukherjee, Soham
;
Singh, Piyush
;
Ghosh, Sujit Kumar
.
BIOPHYSICAL CHEMISTRY,
2021, 269

Ganorkar, Kapil
论文数: 0 引用数: 0
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Visvesvaraya Natl Inst Technol, Dept Chem, Nagpur 440010, Maharashtra, India Visvesvaraya Natl Inst Technol, Dept Chem, Nagpur 440010, Maharashtra, India

论文数: 引用数:
h-index:
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[14]
Exploring the mode of binding between butylated hydroxyanisole with bovine serum albumin: Multispectroscopic and molecular docking study
[J].
Gu, Jiali
;
Zheng, Siyao
;
Huang, Xiyao
;
He, Qian
;
Sun, Ting
.
FOOD CHEMISTRY,
2021, 357

Gu, Jiali
论文数: 0 引用数: 0
h-index: 0
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Northeastern Univ, Dept Chem, Coll Sci, Shenyang 110819, Peoples R China
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Bohai Univ, Coll Chem & Mat Engn, Jinzhou 121013, Peoples R China Northeastern Univ, Dept Chem, Coll Sci, Shenyang 110819, Peoples R China

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论文数: 0 引用数: 0
h-index: 0
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Bohai Univ, Coll Chem & Mat Engn, Jinzhou 121013, Peoples R China Northeastern Univ, Dept Chem, Coll Sci, Shenyang 110819, Peoples R China

He, Qian
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Northeastern Univ, Dept Chem, Coll Sci, Shenyang 110819, Peoples R China Northeastern Univ, Dept Chem, Coll Sci, Shenyang 110819, Peoples R China
[15]
Investigation on the interaction between triclosan and bovine serum albumin by spectroscopic methods
[J].
Gu, Jiali
;
Zheng, Siyao
;
Zhao, Heng
;
Sun, Ting
.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES,
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:52-59

Gu, Jiali
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Sun, Ting
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[16]
Characterization of the interaction between human serum albumin and diazinon via spectroscopic and molecular docking methods
[J].
Hadichegeni, S.
;
Goliaei, B.
;
Taghizadeh, M.
;
Davoodmanesh, S.
;
Taghavi, F.
;
Hashemi, M.
.
HUMAN & EXPERIMENTAL TOXICOLOGY,
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:959-971

Hadichegeni, S.
论文数: 0 引用数: 0
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[17]
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[J].
Hashempour, Shokoufeh
;
Shahabadi, Nahid
;
Adewoye, Aishat
;
Murphy, Brennen
;
Rouse, Camaray
;
Salvatore, Brian A.
;
Stratton, Christopher
;
Mahdavian, Elahe
.
MOLECULES,
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Hashempour, Shokoufeh
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Louisiana State Univ, Dept Chem & Phys, Shreveport, LA 71115 USA
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Louisiana State Univ, Dept Chem & Phys, Shreveport, LA 71115 USA Louisiana State Univ, Dept Chem & Phys, Shreveport, LA 71115 USA
[18]
Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity
[J].
Hostetler, Gregory L.
;
Ralston, Robin A.
;
Schwartz, Steven J.
.
ADVANCES IN NUTRITION,
2017, 8 (03)
:423-435

Hostetler, Gregory L.
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h-index: 0
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Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA

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Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA

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Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA
[19]
Constitutive Polyphenols in Blades and Veins of Grapevine (Vitis vinifera L.) Healthy Leaves
[J].
Kedrina-Okutan, Olga
;
Novello, Vittorino
;
Hoffmann, Thomas
;
Hadersdorfer, Johannes
;
Occhipinti, Andrea
;
Schwab, Wilfried
;
Ferrandino, Alessandra
.
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:10977-10990

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Tech Univ Munich, Fruit Sci, Durnast 2, D-85354 Freising Weihenstephan, Germany Univ Turin, Dept Agr, Forestry, Food Sci DISAFA, Largo P Braccini 2, I-10095 Turin, Italy

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论文数: 引用数:
h-index:
机构:
[20]
Interaction of xylitol with whey proteins: Multi-spectroscopic techniques and docking studies
[J].
Kong, Fanhua
;
Kang, Shimo
;
Tian, Jinlong
;
Li, Mohan
;
Liang, Xiaona
;
Yang, Mei
;
Zheng, Yan
;
Pi, YuZhen
;
Cao, XueYan
;
Liu, YiMing
;
Yue, Xiqing
.
FOOD CHEMISTRY,
2020, 326

Kong, Fanhua
论文数: 0 引用数: 0
h-index: 0
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Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Peoples R China Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Peoples R China

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Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Peoples R China Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Peoples R China

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