Update on Biliary Strictures in Liver Transplants

被引：18

作者：

Sibulesky, L. ^{[1
]}

Nguyen, J. H. ^{[1
]}

机构：

[1] Mayo Clin, Div Transplant Surg, Dept Transplantat, Jacksonville, FL 32224 USA

来源：

TRANSPLANTATION PROCEEDINGS | 2011年 / 43卷 / 05期

关键词：

CARDIAC DEATH DONORS; OF-WISCONSIN SOLUTION; KETOGLUTARATE GRAFT FLUSH; SINGLE-CENTER EXPERIENCE; ISCHEMIC CHOLANGIOPATHY; BILE-DUCT; COLD-STORAGE; RISK-FACTORS; DONATION; PERFUSION;

D O I：

10.1016/j.transproceed.2010.12.057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Biliary complications continue to be the Achilles heel of orthotopic liver transplantation. These include ischemic-type biliary lesions that mostly affect liver allografts donated after cardiac and lead to increased morbidity and retransplantation in patients undergoing liver transplantation. Although this entity has been recognized for > 20 years, the true mechanism of injury remains unknown. Identification of the pathogenesis will likely lead to the increased use of grafts donated after cardiac death and thus increase the organ pool. This update reviews the risk factors that have been implicated in ischernic-type biliary lesion formation, potential therapies, and mechanisms that might lead to their formation.

引用

页码：1760 / 1764

页数：5

共 33 条

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