Objectives, design and main findings until 2020 from the Rotterdam Study

被引：365

作者：

Ikram, M. Arfan ^{[1
]}

Brusselle, Guy ^{[1
,2
]}

Ghanbari, Mohsen ^{[1
]}

Goedegebure, Andre ^{[3
]}

Ikram, M. Kamran ^{[1
,4
]}

Kavousi, Maryam ^{[1
]}

Kieboom, Brenda C. T. ^{[1
]}

Klaver, Caroline C. W. ^{[1
,5
]}

de Knegt, Robert J. ^{[6
]}

Luik, Annemarie I. ^{[1
]}

Nijsten, Tamar E. C. ^{[8
]}

Peeters, Robin P. ^{[7
]}

van Rooij, Frank J. A. ^{[1
]}

Stricker, Bruno H. ^{[1
]}

Uitterlinden, Andre G. ^{[7
]}

Vernooij, Meike W. ^{[1
,9
]}

Voortman, Trudy ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands

[2] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

[3] Erasmus Univ, Med Ctr, Dept Otorhinolaryngol, Rotterdam, Netherlands

[4] Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands

[5] Erasmus Univ, Med Ctr, Dept Ophthalmol, Rotterdam, Netherlands

[6] Erasmus Univ, Med Ctr, Dept Gastroenterol, Rotterdam, Netherlands

[7] Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands

[8] Erasmus Univ, Med Ctr, Dept Dermatol, Rotterdam, Netherlands

[9] Erasmus Univ, Med Ctr, Dept Radiol & Nucl Med, Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2020年 / 35卷 / 05期

关键词：

Biomarkers; Cancer and related diseases; Cardiovascular diseases; Cohort study; Dermatological diseases; Endocrine diseases; Epidemiologic methods; Genetic and molecular epidemiology; Nutrition and lifestyle epidemiology; Liver diseases; Neurological diseases; Oncology; Ophthalmic diseases; Otolaryngological diseases; Pharmacoepidemiology; Population imaging; Renal diseases; Psychiatric diseases; Respiratory diseases; GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; BODY-MASS INDEX; SUDDEN CARDIAC DEATH; SEROTONIN REUPTAKE INHIBITORS; OBSTRUCTIVE PULMONARY-DISEASE; WHITE-MATTER MICROSTRUCTURE; INDIVIDUAL-PARTICIPANT-DATA; HORMONE-BINDING GLOBULIN; CAUSE-SPECIFIC MORTALITY;

D O I：

10.1007/s10654-020-00640-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

引用

页码：483 / 517

页数：35

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