Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases

被引：11

作者：

Marquez, Antonela ^{[1
]}

Andrada, Estefania ^{[1
,2
]}

Russo, Matias ^{[1
]}

Bolondi, Maria Lujan ^{[1
]}

Fabersani, Emanuel ^{[2
]}

Medina, Roxana ^{[1
,2
]}

Gauffin-Cano, Paola ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Ctr Referencia Lactobacilos CERELA, Chacabuco 145,T4000ILC, San Miguel de Tucuman, Tucuman, Argentina

[2] Univ Nacl Tucuman, Fac Agron & Zootecnia, Avda Pte N Kirchner 1900,T4000ILC, San Miguel de Tucuman, Tucuman, Argentina

来源：

HELIYON | 2022年 / 8卷 / 09期

关键词：

Obesity; Diet -induced obesity mice; Caenorhabditis elegans; Functional food; Probiotic fermented food; Fermented dairy products; Lactic acid bacteria; LACTIC-ACID BACTERIA; HIGH-FAT DIET; IN-VITRO; MILK-PRODUCTS; SELECTION; ABILITY; CHEESE; MODEL; SHEEP;

D O I：

10.1016/j.heliyon.2022.e10462

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The present study aimed to design functional fermented goat milk with probiotic potential for metabolic diseases. Thereby, autochthonous lactobacilli from goat dairy products that target improving the inflammatory, lipid, and glycemic profile were characterized. We designed fermented goat milk using Lactobacillus delbrueckii subsp. indicus CRL1447 as starter strain, supplemented with different probiotic consortia formed by Limosilactobacillus fermen-tum CRL1446, Lactiplantibacillus paraplantarum CRL1449, and CRL1472 strains. These lactobacilli were selected for their positive effects on inhibition of alpha-glucosidase, bile salts hydrolase activity, cholesterol assimilation, and decreased triglyceride percentage in Caenorhabditis elegans. Furthermore, the lactobacilli oral administration to obese mice caused a significant decrease in body weight gain and ameliorated hyperglycemia and hyperlipemia. These results reveal the potential of this goat dairy product as a functional food to prevent obesity and related pathologies. Goat milk-derived products stand out for their marketing potential. Hence, fermented goat milk incorporating novel probiotics represents a group of food products with broad prospects by their promising nutritive and therapeutic properties for metabolic diseases. The goat dairy product designed in this study could be used in the prevention of dyslipidemia and hyperglycemia in obese people.

引用

页数：12

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