Perspectives on avian stem cells for poultry breeding

被引:7
作者
Kagami, Hiroshi [1 ]
机构
[1] Shinshu Univ, Fac Agr, Lab Anim Dev Genet, Nagano, Japan
基金
日本学术振兴会;
关键词
chicken; primordial germ cells; poultry breeding; stem cells; PRIMORDIAL GERM-CELLS; CHICK-EMBRYO; CHIMERIC CHICKENS; SEXUAL-DIFFERENTIATION; DEVELOPMENTAL ORIGIN; GALLUS-DOMESTICUS; AREA PELLUCIDA; W-CHROMOSOME; TRANSMISSION; BLASTODERM;
D O I
10.1111/asj.12620
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Stem cells have prulipotency to differentiate into many types of cell lineages. Recent progress of avian biotechnology enabled us to analyze the developmental fate of the stem cells: embryonic stem cells / primordial germ cells (PGCs). The stem cells were identified in the central area of the area pellucida of the stage X blastoderms. These cells could be applied for production of germline chimeras and organ regeneration. Generation of medical substrate in transgenic chickens has considerable interests in pharmaceuticals. Sex alteration of the offspring should be enormously beneficial to the poultry industry. Fertilization of the sex-reversed sperm could lead to sexual alteration of the offspring. These strategies using stem cells / PGCs should be one of the most powerful tools for future poultry breeding.
引用
收藏
页码:1065 / 1075
页数:11
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