Quantitative photoacoustic imaging of two-photon absorption

被引：7

作者：

Bardsley, Patrick ^{[1
]}

Ren, Kui ^{[1
,2
]}

Zhang, Rongting ^{[2
]}

机构：

[1] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA

[2] Univ Texas Austin, Dept Math, Austin, TX 78712 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2018年 / 23卷 / 01期

基金：

美国国家科学基金会;

关键词：

two-photon absorption; photoacoustic tomography; nonlinear diffusion equation; hybrid inverse problems; hybrid imaging; image reconstruction; numerical optimization; THERMOACOUSTIC TOMOGRAPHY; OPTOACOUSTIC TOMOGRAPHY; FLUORESCENT PROTEINS; OPTICAL-ABSORPTION; FEMTOSECOND LASER; RECONSTRUCTION; MICROSCOPY; INVERSION; DISTRIBUTIONS; SCATTERING;

D O I：

10.1117/1.JBO.23.1.016002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Photoacoustic tomography (PAT) is a hybrid imaging modality where we intend to reconstruct optical properties of heterogeneous media from measured ultrasound signals generated by the photoacoustic effect. In recent years, there have been considerable interests in using PAT to image two-photon absorption, in addition to the usual single-photon absorption, inside diffusive media. We present a mathematical model for quantitative image reconstruction in two-photon photoacoustic tomography (TP-PAT). We propose a computational strategy for the reconstruction of the optical absorption coefficients and provide some numerical evidences based on synthetic photoacoustic acoustic data to demonstrate the feasibility of quantitative reconstructions in TP-PAT. (CD) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：11

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