Novel Terpyridine Derivatives of Benzothiazole and Copper(II) Complex: Synthesis and Spectral Studies

被引：0

作者：

Patel, P. N. ^{[1
]}

Desai, D. H. ^{[1
]}

Patel, N. C. ^{[1
]}

机构：

[1] Uka Tarsadia Univ, Dept Chem, Lab Bioorgan Chem, Bardoli 394350, Gujarat, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 58卷 / 01期

关键词：

terpyridine; benzothiazole; multicomponent reaction; one pot synthesis; single crystal X-ray analysis; METAL-COMPLEXES; DNA; NUCLEASE; CLEAVAGE;

D O I：

10.1134/S107042802201016X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel terpyridine derivatives of benzothiazole were synthesised by simple multicomponent one-pot reaction of benzothiazole-2-carbaldehyde, ammonium hydroxide, and isomeric acetyl pyridines with isolated yields of 92-98%. All the prepared derivatives were characterized by NMR, IR, and high-resolution mass spectra. A copper(II) complex was prepared selectively from the terpyridine derivative obtained from 2-acetyl-pyridine and was characterized by single-crystal X-ray analysis. UV-visible spectra were recorded for all the synthesized compounds.

引用

页码：114 / 118

页数：5

共 18 条

[1] Designing metallodrugs with nuclease and protease activity [J].

Agbale, Caleb Mawuli ;

Cardoso, Marlon Henrique ;

Galyuon, Isaac Kojo ;

Franco, Octavio Luiz .

METALLOMICS, 2016, 8 (11) :1159-1169

[2] Time-Dependent Cytotoxic Properties of Terpyridine-Based Copper Complexes [J].

Grau, Jordi ;

Caubet, Amparo ;

Roubeau, Olivier ;

Montpey, David ;

Lorenzo, Julia ;

Gamez, Patrick .

CHEMBIOCHEM, 2020, 21 (16) :2348-2355

[3] The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper-terpyridine compounds [J].

Grau, Jordi ;

Brissos, Rosa F. ;

Salinas-Uber, Jorge ;

Caballero, Ana B. ;

Caubet, Amparo ;

Roubeau, Olivier ;

Korrodi-Gregorio, Luis ;

Perez-Tomas, Ricardo ;

Gamez, Patrick .

DALTON TRANSACTIONS, 2015, 44 (36) :16061-16072

[4] Factors Influencing the DNA Nuclease Activity of Iron, Cobalt, Nickel, and Copper Chelates [J].

Joyner, Jeff C. ;

Reichfield, Jared ;

Cowan, J. A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (39) :15613-15626

[5] Synthesis, characterization, plasmid cleavage and cytotoxicity of cancer cells by a copper(II) complex of anthracenyl-terpyridine [J].

Kumar, Amit ;

Chinta, Jugun Prakash ;

Ajay, Amrendra Kumar ;

Bhat, Manoj Kumar ;

Rao, Chebrolu P. .

DALTON TRANSACTIONS, 2011, 40 (41) :10865-10872

[6] Synthesis, DNA interaction and anticancer activity of copper(II) complexes with 4′-phenyl-2,2′:6′,2"-terpyridine derivatives [J].

Liang, Jie-Wen ;

Wang, Yi ;

Du, Ke-Jie ;

Li, Guan-Ying ;

Dian, Rui-Lin ;

Ji, Liang-Nian ;

Chao, Hui .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 141 :17-27

[7] Copper Complexes as Anticancer Agents [J].

Marzano, Cristina ;

Pellei, Maura ;

Tisato, Francesco ;

Santini, Carlo .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2009, 9 (02) :185-211

[8] Copper complexes as artificial DNA metallonucleases: From Sigman's reagent to next generation anti-cancer agent? [J].

McGivern, T. J. P. ;

Afsharpour, S. ;

Marmion, C. J. .

INORGANICA CHIMICA ACTA, 2018, 472 :12-39

[9] A simple metal free highly diastereoselective synthesis of heteroaryl substituted (±) cyclohexanols by a branched domino reaction [J].

Patel, Paresh N. ;

Chadha, Anju .

TETRAHEDRON, 2018, 74 (01) :204-216

[10] Synthesis, spectroscopic, thermal and biological aspects of drug-based copper(II) complexes [J].

Patel, Paresh N. ;

Patel, Darshana J. ;

Patel, Hasmukh S. .

APPLIED ORGANOMETALLIC CHEMISTRY, 2011, 25 (06) :454-463

← 1 2 →