Type I interferon gene expression:: Differential expression of IFN-A genes induced by viruses and double-stranded RNA

被引：19

作者：

Bragança, J ^{[1
]}

Civas, A ^{[1
]}

机构：

[1] Univ Paris 05, UFR Biomed, Lab Regulat Express Genes Eucaryotes, UPR 37 CNRS, F-75270 Paris 06, France

来源：

BIOCHIMIE | 1998年 / 80卷 / 8-9期

关键词：

IFN-A genes; IFN-B; IRF family; transcription factors; gene regulation;

D O I：

10.1016/S0300-9084(99)80021-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The family of interferon regulatory transcription factors (IRF) participates in the virus-induced and dsRNA-stimulated transcriptional regulation of either type I IFN genes or a definite set of genes which can also be activated by IFN. In this review, we place emphasis on the role of IRF-3 that associates with the coactivators CBP and/or p300, together or not with IRF-7. These complexes bind to the PRDI, PRDI-like domains or to a number of ISRE sequences located in the promoter of these virus-inducible genes. We also discuss the involvement of the IRF-3-related complexes in the differential regulation of IFN-A genes. (C) Societe francaise de biochimie et biologie moleculaire/Elsevier, Paris.

引用

页码：673 / 687

页数：15

共 93 条

[1]

AU WC, 1993, J BIOL CHEM, V268, P24032

[2] DISTINCT ACTIVATION OF MURINE INTERFERON-ALPHA PROMOTER REGION BY IRF-1/ISFG-2 AND VIRUS-INFECTION [J].