Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats

被引：21

作者：

Xing, Ronge ^{[1
]}

He, Xiaofei ^{[1
,2
]}

Liu, Song ^{[1
]}

Yu, Huahua ^{[1
]}

Qin, Yukun ^{[1
]}

Chen, Xiaolin ^{[1
]}

Li, Kecheng ^{[1
]}

Li, Rongfeng ^{[1
]}

Li, Pengcheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China

来源：

MARINE DRUGS | 2015年 / 13卷 / 05期

关键词：

differently regioselective chitosan sulfates; hypoglycemic activity; glucose tolerance; plasma insulin; alloxan-induced diabetic rats; OXIDATIVE STRESS; MECHANISM; FRUIT;

D O I：

10.3390/md13053072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that -OSO3- at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S.

引用

页码：3072 / 3090

页数：19

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