Elevated Temperature Separations on Hybrid Stationary Phases with Low Proportions of Organic Modifier in the Eluent

被引：4
作者：
Al Khateeb, Lateefa A. [1 ,2 ]
Smith, Roger M. [1 ]
机构：
[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
[2] King Abdulaziz Univ, Dept Chem, Jeddah 21413, Saudi Arabia
来源：
CHROMATOGRAPHIA | 2011年 / 73卷 / 7-8期
关键词：
High temperature liquid chromatography; Hybrid stationary phases; Van't Hoff relationships; Methylene selectivity; PERFORMANCE LIQUID-CHROMATOGRAPHY; SUPERHEATED WATER CHROMATOGRAPHY; MODEL-DRUGS; PURE-WATER; MECHANISMS; HPLC;
D O I：
10.1007/s10337-011-1966-x
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The properties of two thermally stable organic/inorganic hybrid columns, XTerra MS C-18 and XTerra phenyl were examined at elevated temperatures, using a number of test compounds, including acetophenone derivatives and phenols, with 5 and 10% methanol in water as the mobile phases. The thermodynamics of the separations were examined. The study demonstrated that a low proportion of organic modifier and moderate temperatures gave similar separations to higher temperature with superheated water, potentially reducing stress on the column and analytes.
引用
收藏
页码：743 / 747
页数：5
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