Development of a pH-responsive imprinted polymer for diclofenac and study of its binding properties in organic and aqueous media

被引:34
作者
Mohajeri, Seyed Ahmad [1 ]
Malaekeh-Nikouei, Bizhan [2 ]
Sadegh, Hasan
机构
[1] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam, Pharmaceut Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Sch Pharm, Nanotechnol Res Ctr, Mashhad, Iran
关键词
Diclofenac; gastrointestinal tract; molecular imprinting; pH-responsive polymer; drug release; SOLID-PHASE EXTRACTION; DRUG-DELIVERY SYSTEMS; ENANTIOSELECTIVE-CONTROLLED DELIVERY; SOFT CONTACT-LENSES; SUSTAINED-RELEASE; CAPILLARY ELECTROCHROMATOGRAPHY; MONOLITHIC COLUMN; WASTE-WATER; ACID; SEPARATION;
D O I
10.3109/03639045.2011.621126
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Three different molecularly imprinted polymers (MIPs) for drug delivery of diclofenac in gastrointestinal tract were synthesized employing bulk polymerization method and their binding and release properties were studied in different pH values. Methacrylic acid (MAA), methacrylamide (MAAM) and 4-vinyl pyridine (4VP) were tested as functional monomers and ethylene glycole dimethacrylate (EDMA) was used as a cross-linker monomer in polymeric feed. Binding properties and imprinting factor (IF) of MIPs were studied in comparison with their non-imprinted ones (Blank) in organic and aqueous media. Diclofenac release in aqueous solvents at pH values of 1.5, 6.0 and 8.0, simulating gastrointestinal fluids, were also studied. The results indicated the specific binding of diclofenac to imprinted polymers. Duo to the stronger non-specific bounds in aqueous solutions, IF values decreased in water compared to acetonitrile as an organic medium. Our results proved that all polymers represented pH-responsive diclofenac delivery at above conditions. The data showed that imprinted polymer, prepared by MAA had superior properties, in comparison with other polymers, for minimum release (14%) of drug in gastric acid and maximum release (90%) in basic condition. The results indicated that diclofenac imprinted polymer could be used as a pH-responsive matrix in preparation of a new drug delivery system for diclofenac.
引用
收藏
页码:616 / 622
页数:7
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