The role of the miR-148/-152 family in physiology and disease

被引：106

作者：

Friedrich, Michael ^{[1
]}

Pracht, Katharina ^{[2
]}

Mashreghi, Mir-Farzin ^{[3
]}

Jaeck, Hans-Martin ^{[2
]}

Radbruch, Andreas ^{[3
]}

Seliger, Barbara ^{[1
]}

机构：

[1] Martin Luther Univ Halle Wittenberg, Inst Med Immunol, Halle, Germany

[2] Univ Erlangen Nurnberg, Dept Internal Med 3, Nikolaus Fiebiger Ctr, Div Mol Immunol, Erlangen, Germany

[3] Deutsch Rheuma Forsch Zentrum DRFZ, Berlin, Germany

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2017年 / 47卷 / 12期

基金：

欧洲研究理事会;

关键词：

Cancer; Diseases; Epigenetic; Lymphocytes; MicroRNA-148/-152; family; miRNA regulation; Post-transcriptional regulation; HLA-G EXPRESSION; INHIBITS CELL-PROLIFERATION; GLIOBLASTOMA STEM-CELLS; GASTRIC-CANCER; TUMOR-SUPPRESSOR; MICRORNA-148A SUPPRESSES; DNA METHYLATION; POSTTRANSCRIPTIONAL REGULATION; HEPATOCELLULAR-CARCINOMA; MESENCHYMAL TRANSITION;

D O I：

10.1002/eji.201747132

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MicroRNAs (miRNAs) are endogenously encoded similar to 22 nt small non-coding RNAs. They function as key players of many cellular processes by base pairing with target mRNAs and thereby impairing gene expression at the post-transcriptional level. Recent findings demonstrate a critical role of many miRNAs in immune cell differentiation and immune responses, which is also associated with the development and progression of many tumor and non-tumor diseases. Here we review the multifaceted miRNA-148/-152 family members consisting of miR-148a, miR-148b and miR-152. Next to regulation mechanisms that control the expression of this miRNA family, we will focus on (i) the role of miR-148a in regulating B and T lymphocyte function and its role in associated diseases and (ii) the importance of miR-148/-152 family members for cancer initiation, tumor growth and metastasis formation. In addition, this review aims to highlight some selected targets of the miRNA-148/-152 family members, which are involved in the biology of cancer and maintenance of epigenetic patterns. In conclusion, members of the miR-148/-152 family might represent prognostic markers and/or potential therapeutic targets for treatment of autoimmune disorders, chronic inflammatory diseases and multiple types of cancer.

引用

页码：2026 / 2038

页数：13

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