Zinc(II) complexes with novel 1,3-thiazine/pyrazole derivative ligands: Synthesis, structural characterization and effect of coordination on the phagocytic activity of human neutrophils

被引：18

作者：

Torres-Garcia, P. ^{[1
]}

Vinuelas-Zahinos, E. ^{[1
]}

Luna-Giles, F. ^{[1
]}

Espino, J. ^{[2
]}

Barros-Garcia, F. J. ^{[1
]}

机构：

[1] Univ Extremadura, Fac Ciencias, Dept Quim Organ & Inorgan, E-06071 Badajoz, Spain

[2] Univ Extremadura, Fac Ciencias, Dept Fisiol, E-06071 Badajoz, Spain

来源：

POLYHEDRON | 2011年 / 30卷 / 15期

关键词：

Thiazine; Pyrazole; Zinc(II) complexes; Crystal structures; Phagocytosis; Human neutrophils; IN-VITRO; COPPER(II); CRYSTAL; IDENTIFICATION; THIAZOLINE; COBALT(II); CD(II); ZN(II);

D O I：

10.1016/j.poly.2011.07.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The new ligands 2-(1-pyrazolil)-1,3-thiazine (PzTz), 2-(3,5-dimethyl-1-pyrazolil)-1,3-thiazine (DMPzTz) and 2-(3,5-diphenyl-1-pyrazolil)-1,3-thiazine (DPhPzTz) and the complexes [ZnCl2(H2O)(PzTz)] (1), [ZnCl2(DMPzTz)] (2) and [ZnCl2(DPhPzTz)] (3) have been isolated and then characterized by elemental analysis, IR spectra and UV-Vis spectroscopy. Besides, the crystal structure of ligands PzTz and DPhPzTz and complexes 1-3 have been determined by single-crystal X-ray diffraction. In 1, the geometry around the Zn(II) atom can be considered a highly distorted trigonal bipyramid, with the metallic atom bonded to two chlorine atoms, one water molecule and one bidentate PzTz ligand. In 2 and 3, the environment around the metal ion can be described as a distorted tetrahedron with the zinc atom coordinated to one bidentate organic ligand molecule and two chloro ligands. In addition, the phagocytic function of human neutrophils treated with complexes 1-3, their organic ligands and ZnCl2 has been evaluated. The activity of cells enhanced in samples treated with 1, 2 and 3 with respect to the ones to which the inorganic salt, PzTz. DMPzTz or DPhPzTz were added. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2627 / 2636

页数：10

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