Reaction of 2-(Benzenesulfonyl)-5-(p-chlorobenzenesulfonyl)-4-tosyl-1,3-thiazole with O-, N-, S-, and C-nucleophiles

被引：1

作者：

Turov, K. V. ^{[1
]}

Drach, B. S. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev 94, Ukraine

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2008年 / 78卷 / 04期

关键词：

EtOH; General Chemistry; Thiazole; Nucleophilic Substitution; Thiazole Ring;

D O I：

10.1134/S1070363208040208

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-(Benzenesulfonyl)-4-tosyl-1,3-thiazole was synthesized starting from the available 2,2-dichloro-1-tosylethenyl isothiocyanate. The product is a pronounced electrophilic substrate feasible for investigation of the order of nucleophilic substitution at the C(2), C(4), and C(5) centers of the thiazole ring. Different nucleophilic agent first attack the C(2) atom. After that S-nucleophiles react with C(5), while O- and N-nucleophiles, with C(4).

引用

页码：629 / 633

页数：5