SALIVARY GLAND CARCINOMAS IN CHILDREN AND ADOLESCENTS: A POPULATION-BASED STUDY, WITH COMPARISON TO ADULT CASES

被引：98

作者：

Sultan, Iyad ^{[1
]}

Rodriguez-Galindo, Carlos ^{[2
,3
]}

Al-Sharabati, Sereen ^{[4
]}

Guzzo, Marco ^{[5
]}

Casanova, Michela ^{[6
]}

Ferrari, Andrea ^{[6
]}

机构：

[1] King Hussein Canc Ctr, Dept Pediat Oncol, Amman, Jordan

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA

[4] Private Dent Clin, Amman, Jordan

[5] Ist Nazl Tumori, Otorhinolaryngol Unit, I-20133 Milan, Italy

[6] Ist Nazl Tumori, Pediat Oncol Unit, I-20133 Milan, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 10期

关键词：

salivary glands; carcinoma; children; adolescents; SEER; prognosis; MUCOEPIDERMOID CARCINOMA; TREP PROJECT; RARE TUMORS; NEOPLASMS; CHILDHOOD; EXPERIENCE; CLASSIFICATION; CANCER;

D O I：

10.1002/hed.21629

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Salivary gland carcinomas are rare malignancies, particularly in young individuals in whom only scanty data are available from published studies. Methods. We searched the SEER database (1973-2006) for patients with a reported diagnosis of salivary gland carcinoma; children/adolescents (< 20 years old) were compared with adults. Results. We identified 263 children/adolescents (58% girls) and 12,571 adults (43% women). The most common histology was mucoepidermoid carcinoma in both groups, but the percentages of other histologies were different. Children/adolescents had more favorable features with most tumors being localized, with no extension to adjacent tissues or lymphatic spread (76% vs 50% in adults, p < .001). Also most tumors were well differentiated or moderately differentiated (88% vs 49% in adults, p < .001). The 5-year overall survival for children/adolescents was 95% +/- 1.5%, compared with 59% +/- 0.5% for adults (p < .001). Conclusion. When compared with adults, salivary gland carcinomas in children/adolescents are less advanced, and have more favorable features and better outcome. Head Neck 33: 1476-1481, 2011

引用

页码：1476 / 1481

页数：6

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