Alterations in the Antioxidant Enzyme Activities in the Neurodevelopmental Rat Model of Schizophrenia Induced by Glutathione Deficiency during Early Postnatal Life

被引：24

作者：

Gorny, Magdalena ^{[1
]}

Bilska-Wilkosz, Anna ^{[1
]}

Iciek, Malgorzata ^{[1
]}

Hereta, Marta ^{[2
]}

Kaminska, Kinga ^{[2
]}

Kaminska, Adrianna ^{[3
]}

Chwatko, Grazyna ^{[3
]}

Rogoz, Zofia ^{[2
]}

Lorenc-Koci, Elzbieta ^{[2
]}

机构：

[1] Jagiellonian Univ, Med Coll, Chair Med Biochem, 7 Kopernika St, PL-31034 Krakow, Poland

[2] Polish Acad Sci, Maj Inst Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland

[3] Univ Lodz, Dept Environm Chem, 163 Pomorska St, PL-90236 Lodz, Poland

来源：

ANTIOXIDANTS | 2020年 / 9卷 / 06期

关键词：

neurodevelopmental model of schizophrenia; GSH deficiency; antioxidant enzymes activity; ROS level; METHIONINE SULFOXIDE REDUCTASES; DOPAMINE UPTAKE INHIBITION; CYSTEINE LIGASE MODIFIER; OXIDATIVE STRESS; REACTIVE OXYGEN; PREFRONTAL CORTEX; HYDROGEN-PEROXIDE; SULFANE SULFUR; ATOM TRANSFER; BRAIN;

D O I：

10.3390/antiox9060538

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present study was to assess the effects ofl-buthionine-(S,R)-sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor, and GBR 12909, a dopamine reuptake inhibitor, administered alone or in combination to Sprague-Dawley rats during early postnatal development (p5-p16), on the levels of reactive oxygen species (ROS), lipid peroxidation (LP) and the activities of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione disulfide reductase (GR) in peripheral tissues (liver, kidney) and selected brain structures (prefrontal cortex, PFC; hippocampus, HIP; and striatum, STR) of 16-day-old rats. The studied parameters were analyzed with reference to the content of GSH and sulfur amino acids, methionine (Met) and cysteine (Cys) described in our previous study. This analysis showed that treatment with a BSO + GBR 12909 combination caused significant decreases in the lipid peroxidation levels in the PFC and HIP, in spite of there being no changes in ROS. The reduction of lipid peroxidation indicates a weakening of the oxidative power of the cells, and a shift in balance in favor of reducing processes. Such changes in cellular redox signaling in the PFC and HIP during early postnatal development may result in functional changes in adulthood.

引用

页码：1 / 25

页数：24

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